Smad2/3PP2AROCKp38PI3KAktmTORMKK3/6CBPSmad4Smad1/5/8Smad1/5/8Smad4Smad2/3Smad2/3Smad2/3RasSOSErk1/2Smad1/5/8Smad1/5/8Smad4Smad4Smad2/3Smad2/3CBPSmad4Smad1/5/8Smad1/5/8JNKp38MKK3/6MKK4TGF-βLigands:TGF-βs,Activins,NodalsBMPLigands:BMP-2,-4,-7,MISPar6SARARhoATAK1/MLK3/MEKK1Smurf2Smad6Smad7Smad7GRB2ShcRac/Cdc42PKCmDiaPAKMLCLIMKCofilinc-AblSmurf1TFTFLIMKCofilinp70S6KTypeIReceptorTypeIIReceptorTypeIReceptorTypeIIReceptorActinPolymerizationStressFibersTranscriptionFactors:AP-1bZIPRUNXFoxbHLHhomeodomainSp1nuclearreceptorsIRF-7Corepressors:c-Ski/SnoNc-MycEvi1TGIFSIP1Tob(BMPonly)Coactivators:CBP/p300SMIFMSG1ARC105CellAdhesionActinPolymerizationStressFibersNucleusCytoplasmTGF-βSignalingwww.cellsignal.com©2003–2011CellSignalingTechnology,Inc.TGF-βSignaling•createdJanuary2003•revisedNovember2011DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
