WTXTAB1TAB2SFRPSFRPWIFWntDKKsFrizzledFrizzledAPCβ-TrCPGrouchoICATChibbyLEF/TCFDvlDvlDvlNakedPAR-1LRPAxinPP2ACK1AxinLEF/TCFPygoBCL9RAFerα-cateninp120RTKLRPGrouchoProp1Prop1β-cateninβ-cateninβ-cateninHDACCYLDTankyraseHDACCBPβ-cateninGBPNLKNLKRac1Cdk8RARSrcGSK-3GSK-3β-cateninTAK1ubCadherinCK1TGF-β/BMPubβ-cateninβ-cateninubOFFHesx1TargetGenes:Myc,CyclinD1,TCF-1,PPAR-δ,MMP-7,Axin-2,CD44,etc.ON-StateOFF-StateNucleusCytoplasmMigrationmTORPathwayAdhesionProteasomalDegradationPit1Wnt/β-CateninSignalingwww.cellsignal.com©2003–2010CellSignalingTechnology,Inc.Wnt/β-CateninSignaling•createdJanuary2003•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
