cdc42Par6aPKCPar3Rac1Rac1TauRhoRhomDIAmDIA1ErkDvlTAOKMARKMARK2TESKSpred1CofilinLIMKTPPPLL5βPar1AktPTENROCKPI3KGαq/oWntLRPAPCAPCmDIAEB1CLASPCLASPEB1EB1CLIPCLIPStat3ICISMAP1bXMAP215MCAKMAP1bCRMP2MAPKAPPKGSK-3βPKACaMKCdk1AuroraBPAKErkStathminCLIPCLIPcAblTrioTiam1SrcRhoGαRhoRhoGEFRTKNeurotrophinsDeliverytoMTPlusEndsMTStabilityPlusEndProteinsActinFilamentsMTPolymerizationMTPolymerizationPlusEndMinusEnd+endGrowthPromoting+/-endDestabilizingMTCatastrophe“DynamicMicrotubules”FocalAdhesionsPIP3PIP3©2008–2010CellSignalingTechnology,Inc.RegulationofMicrotubuleDynamics•createdSeptember2008•revisedNovember2010RegulationofMicrotubuleDynamicswww.cellsignal.comDirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
