COREPATHWAYWartsYkiYkiYkiYkiYAPCOREPATHWAYActinActinRASSFWILLIN/FRMD6PP2AMST1/2LATS1/2ITCHASPP1ASPP1MDM2p53CK1βTRCPZO-2SMADAJUBαCATENINCrumbspolaritycomplex-AMOTDcoFatFatDSExCrbDachsKibraMerKIBRAMERdSTRIPAKPP2acomplexRassfMatsSav14-3-3LftTightjunctionWbp2AntiapoptosisproliferationCTGFAREGGli2Birc5-2FGFProteasomeSRC/ABLRunx2,Smad,Pax3,Tbx5,TTF-1,PPARa,DNp63CD44AdherensjunctionSeptatejunctionAdherensjunctionAppdJubdJubHippoMOBExp53SdNUCLEUSPPPPPFatFatFatFatPFatPPYAP/TAZYAP/TAZYAP/TAZYAP/TAZYAP/TAZYAP/TAZWbp-2YAP/TAZNUCLEUSNUCLEUSMorphogengradientregulationdally,dallyLProproliferationbantam,cyclinEAntiapoptosisdiap1Negativefeedbackex,kibra,dally,fjCrosstalktotheEFGR,Wingless,andNOTCHpathwaysvein,wg,serp73TEAD1/4CELLDENSITYWartsPSavPMatsPSavSavPMOBPLATS1/2PHippoPMST1/2SavPYAP/TAZPYAP/TAZYAP/TAZYAP/TAZPYAP/TAZUbYkiPCOREPATHWAYYkiPPYkiPPPDcoP14-3-314-3-3Hth,Tsh,MadDNADAMAGEYAP/TAZPYAP/TAZPYAP/TAZYAP/TAZPYAP/TAZPYAP/TAZYAP/TAZPYAP/TAZYAP/TAZUbUbPYAPαCATENINPYAP/TAZYAP/TAZYAP/TAZP14-3-3YAP/TAZYAP/TAZYAP/TAZPYAP/TAZYAP/TAZYAP/TAZPProapoptosisgenesERGOLGIPPPFjFjFjFjFjFjFjFjFjFjFjFjFjFjFjFjFjFjPLglScribbleDlgLglScribbleDlgMammalsDrosophilaSeeonlineversionforlegendandreferences.484Cell145,April29,2011©2011ElsevierInc.DOI10.1016/j.cell.2011.04.009SnapShot:TheHippoSignalingPathwayCarolineBadouelandHelenMcNeillSamuelLunenfeldResearchInstitute,DepartmentofMolecularGenetics,UniversityofToronto,MountSinaiHospital,600UniversityAvenue,Toronto,ONM5G1X5,Canada484.e1Cell145,April29,2011©2011ElsevierInc.DOI10.1016/j.cell.2011.04.009SnapShot:TheHippoSignalingPathwayCarolineBadouelandHelenMcNeillSamuelLunenfeldResearchInstitute,DepartmentofMolecularGenetics,UniversityofToronto,MountSinaiHospital,600UniversityAvenue,Toronto,ONM5G1X5,CanadaTheHipposignalingpathwaycontrolstissuegrowthandappearstobecriticalinthe“organsize”checkpoint.ThispathwaywasfirstdiscoveredinDrosophilaandiswellcon-servedinmammals.MutationsinHippopathwaycomponentshavebeenlinkedtonumerouscancers,includingthoseoftheb...
