N-PTPPIASSHP1SOCSCISTFTFp120ras-GAPSOCS3SUMOStat3ErkmTORAktShcGRB2RasPI3KSHP2ErkMEKRafStat3Stat3StatStatMcl-1JakJakStat3gp130EGFRSrcEGFErkErkIL-6CIS,SOCS,Mcl-1,APPs,TIMP-1,Pim-1,c-Myc,cytokines,TFs,etc.CrosstalkTumorCellsApoptosisRenewalofESCellsC/EBPβNF-κBAP-1etc.NucleusCytoplasmFeedbackInhibitionISRE/GASAccessoryTFMotifE-RasAktPI3KTumor-likePropertiesofESCellsJak/StatSignaling:IL-6ReceptorFamilywww.cellsignal.com©2002–2010CellSignalingTechnology,Inc.Jak/StatSignaling:IL-6ReceptorFamily•createdNovember2002•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
