MERKIBRAMERFRMD6FRMD6SAV114-3-314-3-3MOB1Mst1/2SAV1DvICK1Mst1/2LATS1/2MOB1LATS1/2YAPYAP/TAZYAP/TAZYAP/TAZYAPTFTFTFYAPTAZTAZTAZKIBRARassfDCHS1/2DCHS1/2FAT4FAT4FAT4Wnt/β-CateninSignalingUbiquitinationDegradationTranscriptionFactors(TF)include:TEAD,TEF,RunX1,RunX2,p73PPARγandothersGrowthandDifferentiationGrowthandDifferentiationCytoplasmNucleusNucleusCytoplasmCytoplasmCytoplasmHighCelldensityLowCelldensityGrowthandDifferentiationHippoSignalingwww.cellsignal.com©2010–2011CellSignalingTechnology,Inc.HippoSignaling•createdNovember2010•revisedJune2011DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
