黄正上海有机化学研究所金属有机国家重点实验室地址：君谋楼1103电话：54925522Email：huangzh@sioc.ac.cnPericyclicReaction•I.HistoryReview•II.ClassificationofPericyclicReaction•III.FrontierMolecularOrbital(FMO)Theory•IV.OrbitalCorrelationDiagrams•V.AromaticTransitionStateTheoryRB.Woodward•BSandPhDatMIT,PostdocatUIUC•1965NobelprizeforTotalSynthesis(奎宁、胆固醇、可的松…)•EstablishedOrbitalCorrelationDiagramswithHoffmann.WoodwardHoffmannrule(Crorotation,disrotation)•DeducethestructureofferrocenebasedonitsreactivitywithG.Wilkinson.•Structure,mechanism,synthesis•Studentsorpostdocs:Kishi,Foote,Houk,Breslow,Schreiber,Roush…I.HistoryReview(1)物理有机化学家物理有机化学家RB.WoodwardRonaldBreslow(formerpresidentofACS;Cyclopropenylcation---thesimplestaromaticsystem;biomimeticchemistry)RobertGrubbs(Organometallicchemist,Olefinmetathesiscatalyst,2005NobelprizeinChemistry)EricAnslynSaulWinstein:1912-1969.Proposedathree-centertwo-electronbondstructureof2-nobonylcation.ArguedbyH.C.Brownwhosupportedaclassisresonancestructure.InvestigatedbyLowTNMR,Raman…Changedtheviewoftheactivityofsigmabond.MauriceBrookhart:PhDwithWinstein,Agosticinteraction(InteractionbetweenmetalandC-Hbond),C-Hbondactivation,late-transition-metalolefinpolymerizationcatalyst,mechanisticstudiesbyNMRRichardF.Heck:1952-54,PhDwithWinstein,Pd-catalyzedarylmercurywitholefin,7consecutiveJACSpaperin1968(soleauthor);InspiredtheresearchofPd-catalyzedcouplingreactions.2010NoblePrize.RobertBergman(Early:physicalorganicchemist,knownforBergmanreaction,共轭烯二炔电环化反应；Late:organometallicchemist,thepioneerinC-Hbondactivationandfunctionalization)JohnF.Hartwig(Organometallicchemist,C-Hbondfunctionalization,C-Nbondcrosscoupling,etc.Mechanisticstudiesleadtonewreactions)Physicalorganicchemistryisaliveandwellintheearlytwenty-firstcentury.Nowlifehasbeenbreathedintothefieldbecauseithasembracednewerchemicaldeciplines,suchasbioorganic,organometallic,materials,andsupramolecularchemistries…Organometallicchemistrytracesitsin...
