��国际妇产科学杂志2023年6月第50卷第3期JIntObstetGynecol，June2023，Vol.50，No.3携带CTNNB1突变的早期子宫内膜样癌一例及文献复习杨鸣，陈明珠，田书屹，刘小艳，张立会【摘要】近年子宫内膜癌发病率呈上升趋势，且趋于年轻化。大部分的子宫内膜癌是低级别、早期子宫内膜样癌，预后良好。然而，部分低级别、早期子宫内膜样癌患者易复发且预后较差，早期识别这些高危患者有助于确定哪些患者需要额外的辅助治疗和更密切的随访。近年来CTNNB1突变被认为是此类患者潜在的复发风险因素，具有独立的预后价值，但到目前为止对于低级别、早期且伴有CTNNB1突变的子宫内膜样癌患者是否需要辅助治疗尚无明确的指南。结合收治的1例ⅠA期、低级别、伴有CTNNB1基因突变的子宫内膜样癌患者诊治情况，对该基因突变加以探讨，以期提高对具有此类突变患者的预后及后续治疗的进一步认识。【关键词】子宫内膜肿瘤；CTNNB1基因；突变；基因检测；治疗；预后EarlyEndometrioidCarcinomawithCTNNB1Mutation:ACaseReportandLiteratureReviewYANGMing,CHENMing-zhu,TIANShu-yi,LIUXiao-yan,ZHANGLi-hui.DepartmentofObstetricsandGynecology,TheSecondHospitalofJilinUniversity,Changchun130041,ChinaCorrespondingauthor:ZHANGLi-hui,E-mail:lihui3572@sina.com【Abstract】Theincidenceofendometrialcarcinomahasbeenincreasinginrecentyears,andtheageofonsetistendstoyounger.Mostendometrialcarcinomasarelow-grade,early-stageendometrioidcarcinomas(EECs)withagoodprognosis.However,somepatientswithlow-grade,early-stageEECsarepronetorecurrenceandhaveapoorprognosis.Earlyidentificationofthesehigh-riskpatientswithEECscanhelpdeterminewhichpatientsneedadditionaladjuvanttherapyandcloserfollow-up.Inrecentyears,CTNNB1mutationhasbeenconsideredasapotentialriskfactorforrecurrence,whichhasindependentprognosticvalue.Butsofar,therearenoclearguidelinesonwhetheradjuvanttherapyisneededforlow-gradeandearly-stageEECspatientswithCTNNB1mutation.CombinedwithapatientwithanⅠAstage,low-gradepatientwithCTNNB1genemutationinourhospital,thisgenemutationismainlydiscussedinordertoimproveclinicians′furtherunderstandingoftheprognosisandfollow-uptreatmentofpatientswithsuchmutation.【Keywords】Endometrialneoplasms;CTNNB1ge...
