CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyWarburgEffectPDHKIDH1IDH2PHGDHRasRasRasUCP2ACSS2MalateMalateCitrateCitrateAcetateEpigeneticRegulationACLACCLDHAPyruvateDehydrogenaseNADPHNADPHNADPHNADPNADPNADPMalicEnzymeGlutaminaseOxaloacetateGlutamineTransportersGlucoseTransportersHexokinasePFKPKM2Acetyl-CoAGlutamineOMMStabilityInhibitionCytochromeCReleaseInhibitionofApoptosisGlutaminolysisAcetyl-CoAPyruvatePyruvate6-P-Gluconolactone6-P-GluconateAminoAcidsandLipidsRibulose-5PNucleotideSynthesisFolateMetabolismFructose-6-PFructoseBisphosphate3-PhosphoglyceratePEPGlucose-6-PLactateSerineGlycineKrebsCycleVDACHexokinaseBaxVDACANTANTα-Ketoglutarateβ-OxidationMEK1/2AMPKp53TIGARc-Mycc-MycAMPKc-MycHIF-1αHIF-1αSREBPLKB1ULK1c-MycErk1/2AktAktmTORNADPHNADPNADPHNADPPI3Kp53AminoAcidsCellProliferationFattyAcidOxidationAutophagyFattyAcidsFattyAcid/LipidSynthesisProteinSynthesisGrowthFactorsMacropinocytosisandotherscavengingpathwaysGlucoseGlycolysisPentosePhosphateShunt
