Seeonlineversionforlegend,abbreviations,andreferences.192Cell133,April4,2008©2008ElsevierInc.DOI10.1016/j.cell.2008.03.010SnapShot:TheSplicingRegulatoryMachineryMathieuGabut,SidharthChaudhry,andBenjaminJ.BlencoweBantingandBestDepartmentofMedicalResearch,UniversityofToronto,Toronto,ONM5S3E1,CanadaAmyCebHipHypOBEyeSCBMBoHtSMEpdKdLivLuPanPlaProStoSplThyThdTeUtOvE6.5E8.5E10.5SRandSR-RelatedProteinsNameOtherNamesProteinDomainsBindingSitesTargetGenes/MousePhenotypes/DiseaseAssociationsSRp20Sfrs3,X16RRM,RSGCUCCUCUUCSRp20,CT/CGRP;−/−earlyembryoniclethalE3.59G8Sfrs7RRM,RS,C2HCZnf(GAC)nTau,GnRH,9G8ASF/SF2Sfrs1RRM,RSRGAAGAACHipK3,CaMKIIδ,HIVRNAs;−/−embryoniclethal,cond.KOcardiomyopathySC35Sfrs2RRM,RSUGCUGUUAChE;−/−embryoniclethal,cond.KOdeficientT-cellmaturation,cardiomyopathy;LSSRp30cSfrs9RRM,RSCUGGAUUGlucocorticoidreceptorSRp38Fusip1,NssrRRM,RSACAAAGACAACREB,typeIIandtypeXIcollagensSRp40Sfrs5,HRSRRM,RSAGGAGAAGGGAHipK3,PKCβ-II,FibronectinSRp55Sfrs6RRM,RSGGCAGCACCUGcTnT,CD44SRp75Sfrs4RRM,RSGAAGGAFN1,E1A,CD45;overexpressionenhanceschondrogenicdifferentiationTra2αTra2aRRM,RSGAAARGARRGnRH;overexpressionpromotesRA-inducedneuraldifferentiationTra2βSfrs10RRM,RS(GAA)nHipK3,SMN,TauSRm160Srrm1RS,PWIAUGAAGAGGACD44SWAPSfrs8RS,SWAPNDSWAP,CD45,Tau;possibleasthmasusceptibilitygenehnRNPProteinshnRNPA1Hnrnpa1RRM,RGGUAGGGA/UHipK3,SMN2,c-H-ras;rheumatoidarthritis,systemiclupuserythematosushnRNPA2/B1Hnrnpa2b1,Hnrnpa2RRM,RGG(UUAGGG)n4.1R,HIVTat,IKBKAP;rheumatoidarthritis,systemiclupuserythematosushnRNPCHnrnpc,Hnrnpc1/c2RRMU-richβ-amyloidreceptor;−/−embryoniclethalE6.5;systemicsclerosis,psoriaticarthritishnRNPFHnrpfRRM,RGG,GYGGGA,G-richPLP,c-SRC,Bcl-xhnRNPGRbmxrt,HnrnpgRRM,RGG,SRGYAAGUSMN2,α-tropomyosin;−/−impairedspermatogenesishnRNPHHnrph1RRM,RGG,GYR,GYGGGA,G-richPLP,HIVtat,Bcl-x;possibleimplicationinMDhnRNPLHnrnplRRMC/A-richeNOS,CD45;systemicrheumaticdiseasesPTBPtbp1,HnrpiRRMUCUU,CUCUCUnPTB,c-SRC,Fas,cTNT,CGRP,NMDA,CLBC,hnRNPA1nPTBPtbp2,brPTBRRMCUCUCUc-SRC,GlyRα2OtherFactor...
