RepurposingGenerationoftelomeraseRNAGenerationofcircularRNAs......Exon6Exon7Exon8hnRNPA1/A2ISSSMN2......Exon6Exon7Exon8hnRNPA1/A2SMN2ASOSmallmoleculesandantisenseoligonucleotides......Exon1Exon43'3'......Exon1A.ExonskippingB.Intronpairing......Exon1Exon2Exon2Exon2Exon2Exon2Exon2Exon2Exon3Exon3Exon3Exon3Exon3Exon3Exon3Exon4BPBPBP......Forkedproduct(terminated)Intron2lariat3'DoublelariatIntra-lariatsplicingCircularRNA12...Exon1Exon1...Step2Step1...ActivetelomeraseMatureTER1(telomeraseRNA)XSMN2......Exon7U1NVS-SM1Exon8Intron7Exon7inclusionSMN2-Centromericsurvivalofmotorneuron2geneU2...U2SSAAp14Decoy-BPS...5'3'5'3'BPSExonExonSSA-spliceostatinADMD-DuchennemusculardystrophygeneDantrolene......Exon48Exon51Exon52DMDmutASOIntron48/50......Exon48Exon51Exon52Stop......Exon48Exon51Exon52DMDmutIntron48/50C-terminallytruncated,non-functionaldystrophinprotein......Exon48Exon52Internallydeleted,partlyfunctionaldystrophinproteinIndirectlyviaCa2+signaling?......U2SF3b155p145'3'U2SF3b155p145'3'Prp5ATPE7107ABPSDiseaselinksU2AF65U2AF35U2snRNAU2snRNPSF3b155p14AExon1Exon2MyelodysplasticsyndromesChroniclymphocyticleukaemiaChangesleadingtohaplo-insuffciencyordominantnegativeeffectsSpinalmuscularatrophySmproteinssnRNASMNSmsiteU6atacU4atacTaybi-Lindersyndrome(MOPDI)U2AF65U2AF35SF1/BBPExon1AExon2MyelodysplasticsyndromesU1U2APPTSRSF135U2AF65...ChronicmyelomonocyticleukemiahPrp8hBrr2hPrp6hPrp31hPrp3hPAP-1RetinitispigmentosaRRMRRMRRMRRMISSU6U4U5SF3b155SF3b155OOAcONHOOOOOOOOHHNNNNNO–N+OHNNNOHONNOOHOHOOOOHOHSeeonlineversionforlegendsandreferences.690Cell162,July30,2015©2015ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2015.07.033SnapShot:SpliceosomeDynamicsIIIMarkusC.Wahl1andReinhardLührmann21LaboratoryofStructuralBiochemistry,FreieUniversitätBerlin,Takustraße6,14195Berlin,Germany2DepartmentofCellularBiochemistry,MaxPlanckInstituteforBiophysicalChemistry,AmFassberg11,37077Göttingen,Germany690.e1Cell162,July30,2015©2015ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cell.2015.07.033SnapShot:S...
