ArticlePD-L1(B7-H1)CompeteswiththeRNAExosometoRegulatetheDNADamageResponseandCanBeTargetedtoSensitizetoRadiationorChemotherapyGraphicalAbstractHighlightsdIntracellularPD-L1bindsRNAandregulatestheRNAstabilityofDNAdamagegenesdPD-L1competeswiththeRNAexosometoregulateRNAstabilitygloballydPD-L1isimportantforproperDNAdamageresponseandrepairdThePD-L1antibodyH1AsensitizestumorstoDNA-damagingtherapyAuthorsXinyiTu,BoQin,YongZhang,...,HaidongDong,RobertW.Mutter,ZhenkunLouCorrespondencedong.haidong@mayo.edu(H.D.),mutter.robert@mayo.edu(R.W.M.),lou.zhenkun@mayo.edu(Z.L.)InBriefTuetal.demonstratedthatintracellularPD-L1regulatestheDNAdamageresponsebybindingandstabilizingthemRNAsofDNAdamagegenes.Furthermore,anovelPD-L1antibody,H1A,cansensitizecancertoDNA-damagingtherapybypromotingPD-L1degradation.Tuetal.,2019,MolecularCell74,1215–1226June20,2019ª2019ElsevierInc.https://doi.org/10.1016/j.molcel.2019.04.005MolecularCellArticlePD-L1(B7-H1)CompeteswiththeRNAExosometoRegulatetheDNADamageResponseandCanBeTargetedtoSensitizetoRadiationorChemotherapyXinyiTu,1,2,6BoQin,2,6YongZhang,2,6ChengZhang,3MohamedKahila,1SomairaNowsheen,2PingYin,2JianYuan,2HuadongPei,5HuLi,3JiaYu,3ZhiwangSong,2QinZhou,2FeiZhao,2JiaqiLiu,2ChaoZhang,2HaidongDong,4,*RobertW.Mutter,1,*andZhenkunLou2,3,7,*1DepartmentofRadiationOncology,MayoClinic,Rochester,MN55905,USA2DepartmentofOncology,MayoClinic,Rochester,MN55905,USA3DepartmentofMolecularPharmacologyandExperimentalTherapeutics,MayoClinic,Rochester,MN55905,USA4DepartmentofUrology,MayoClinic,Rochester,MN55905,USA5DepartmentofBiochemistryandMolecularMedicine,GeorgeWashingtonUniversitySchoolofMedicineandHealthScience,2300EyeStreet,NW,Washington,DC20037,USA6Theseauthorscontributedequally7LeadContact*Correspondence:dong.haidong@mayo.edu(H.D.),mutter.robert@mayo.edu(R.W.M.),lou.zhenkun@mayo.edu(Z.L.)https://doi.org/10.1016/j.molcel.2019.04.005SUMMARYProgrammeddeathligand1(PD-L1,alsocalledB7-H1)isanimmunecheckpointproteinthatinhibitsimmunefunctionthroughitsbindingofthepro...
