ARTICLEcircTP63functionsasaceRNAtopromotelungsquamouscellcarcinomaprogressionbyupregulatingFOXM1ZhuoanCheng1,6,ChengtaoYu1,6,ShaohuaCui2,6,HuiWang3,HaojieJin3,CunWang3,BotaiLi1,MeilinQin3,ChenYang4,JiaHe3,QiaozhuZuo3,SiyingWang3,JunLiu2,WeidongYe5,YuanyuanLv3,FangyuZhao3,MingYao3,LiyanJiang2&WenxinQin1,3CircularRNAs(circRNAs)areidentifiedasvitalregulatorsinavarietyofcancers.However,theroleofcircRNAinlungsquamouscellcarcinoma(LUSC)remainslargelyunknown.Herein,weexploretheexpressionprofilesofcircRNAandmRNAin5pairedsamplesofLUSC.Byanalyzingtheco-expressionnetworkofdifferentiallyexpressedcircRNAsanddysregulatedmRNAs,weidentifythatacellcycle-relatedcircRNA,circTP63,isupregulatedinLUSCtissuesanditsupregulationiscorrelatedwithlargertumorsizeandhigherTNMstageinLUSCpatients.ElevatedcircTP63promotescellproliferationbothinvitroandinvivo.Mechanistically,circTP63sharesmiRNAresponseelementswithFOXM1.circTP63competi-tivelybindstomiR-873-3pandpreventsmiR-873-3ptodecreasethelevelofFOXM1,whichupregulatesCENPAandCENPB,andfinallyfacilitatescellcycleprogression.https://doi.org/10.1038/s41467-019-11162-4OPEN1StateKeyLaboratoryofOncogenesandRelatedGenes,ShanghaiCancerInstitute,RenjiHospital,ShanghaiJiaoTongUniversitySchoolofBiomedicalEngineering,200032Shanghai,China.2DepartmentofRespiratoryMedicine,ShanghaiChestHospital,ShanghaiJiaoTongUniversity,200030Shanghai,China.3ShanghaiCancerInstitute,RenjiHospital,ShanghaiJiaoTongUniversitySchoolofMedicine,200032Shanghai,China.4ShanghaiMedicalCollegeofFudanUniversity,200032Shanghai,China.5DepartmentofGeneralSurgery,ShanghaiJiaoTongUniversityAffiliatedSixthPeople’sHospital,200233Shanghai,China.6Theseauthorscontributedequally:ZhuoanCheng,ChengtaoYu,ShaohuaCui.CorrespondenceandrequestsformaterialsshouldbeaddressedtoL.J.(email:jiang_liyan2000@126.com)ortoW.Q.(email:wxqin@sjtu.edu.cn)NATURECOMMUNICATIONS|(2019)10:3200|https://doi.org/10.1038/s41467-019-11162-4|www.nature.com/naturecommunications11234567890():,;Lungcanceristhemostcommonincidentcance...
