ArticleAutophagy-DependentGenerationofFreeFattyAcidsIsCriticalforNormalNeutrophilDifferentiationGraphicalAbstractHighlightsdAutophagyiscriticalforneutrophildifferentiationinvivodDifferentiatingneutrophilsshiftfromglycolysistofattyacidoxidationdBydegradinglipiddroplets,autophagyprovidesfattyacids,enablingthisshiftdFattyacidsrestoreenergymetabolismanddifferentiationinAtg7–/–granulopoiesisAuthorsThomasRiffelmacher,AlexanderClarke,FelixC.Richter,...,HolmUhlig,StenEirikW.Jacobsen,AnnaKatharinaSimonCorrespondencekatja.simon@ndm.ox.ac.ukInBriefRapidneutrophildifferentiationiskeytotheimmuneresponseagainstinvadingbacteria.Here,Riffelmacheretal.showthatautophagy,themainrecyclingprocessinthecell,providesenergyforneutrophildifferentiationbydegradinglipiddroplets.Thisopenspossiblenoveltherapeuticavenuesforthedifferentiationtreatmentofgranulocyticleukemia.Riffelmacheretal.,2017,Immunity47,1–15September19,2017ª2017TheAuthors.PublishedbyElsevierInc.http://dx.doi.org/10.1016/j.immuni.2017.08.005ImmunityArticleAutophagy-DependentGenerationofFreeFattyAcidsIsCriticalforNormalNeutrophilDifferentiationThomasRiffelmacher,1,2AlexanderClarke,1FelixC.Richter,1AmandaStranks,2SumeetPandey,6SaraDanielli,2PhilipHublitz,3ZhanruYu,4ErrinJohnson,5TobiasSchwerd,6JamesMcCullagh,7HolmUhlig,6StenEirikW.Jacobsen,3,8,9,10,11andAnnaKatharinaSimon1,2,11,12,*1KennedyInstituteofRheumatology,UniversityofOxford,RooseveltDrive,OxfordOX37FY,UK2MRCHumanImmunologyUnit,WeatherallInstituteofMolecularMedicine,UniversityofOxford,JohnRadcliffeHospital,Headington,OxfordOX39DS,UK3MRCMolecularHematologyUnit,WeatherallInstituteofMolecularMedicine,UniversityofOxford,JohnRadcliffeHospital,Headington,OxfordOX39DS,UK4TargetDiscoveryInstitute,NuffieldDepartmentofMedicine,UniversityofOxford,RooseveltDrive,OxfordOX37FZ,UK5TheDunnSchoolofPathology,SouthParksRoad,OxfordOX13RE,UK6TranslationalGastroenterologyUnit,ExperimentalMedicine,UniversityofOxford,JohnRadcliffeHospital,OxfordOX39DU,UK7ChemistryResearchLaboratory,Departme...
