CancerCellArticleTumorVesselNormalizationbyChloroquineIndependentofAutophagyHanneloreMaes,1,15AnnaKuchnio,2,3,15AleksandarPeric,4StijnMoens,2,3KrisNys,1KatrienDeBock,2,3AnneliesQuaegebeur,2,3SandraSchoors,2,3MariaGeorgiadou,2,3JasperWouters,5,6StefanVinckier,2,3HugoVankelecom,6MarjanGarmyn,7Anne-Cle´menceVion,8FreddyRadtke,9,10ChantalBoulanger,8HolgerGerhardt,11,12,13ElisabettaDejana,14MiekeDewerchin,2,3BartGhesquie`re,2,3WimAnnaert,4PatriziaAgostinis,1,*andPeterCarmeliet2,31DepartmentCellularandMolecularMedicine,LaboratoryofCellDeathandTherapy,KULeuven,B-3000Leuven,Belgium2DepartmentofOncology,LaboratoryofAngiogenesisandNeurovascularLink,KULeuven,B-3000Leuven,Belgium3VesaliusResearchCenter,LaboratoryofAngiogenesisandNeurovascularLink,VIB,B-3000Leuven,Belgium4DepartmentofHumanGeneticsandVIB-CenterfortheBiologyofDisease,LaboratoryforMembraneTrafficking,B-3000Leuven,Leuven3000,Belgium5DepartmentofImaging&Pathology,TranslationalCellandTissueResearch,KULeuven,B-3000Leuven,Belgium6DepartmentofDevelopmentandRegeneration,EmbryoandStemCellsUnit,KULeuven,B-3000Leuven,Belgium7DepartmentofOncology,LaboratoryDermatology,KULeuven,B-3000Leuven,Belgium8CardiovascularResearchCenter,INSERMUMR-970,ParisCedex15,France9EcolePolytechniqueFe´de´raledeLausanne,SchoolofLifeScience,1015Lausanne,Switzerland10SwissInstituteforExperimentalCancerResearch,1015Lausanne,Switzerland11VascularBiologyLaboratory,LondonResearchInstitute,CancerResearchUK,LondonWC2A3LY,UK12DepartmentofOncology,VascularPatterningLaboratory,KULeuven,B-3000Leuven,Belgium13VesaliusResearchCenter,VascularPatterningLaboratory,VIB,B-3000Leuven,Belgium14VascularBiologyProgram,IFOM,FIRCInstituteofMolecularOncologyFoundation,20139Milan,Italy15Co-firstauthor*Correspondence:patrizia.agostinis@med.kuleuven.behttp://dx.doi.org/10.1016/j.ccr.2014.06.025SUMMARYChloroquine(CQ)hasbeenevaluatedasanautophagyblockerforcancertreatment,butitisunknownifitactssolelybyinhibitingcancercellautophagy.WereportthatCQreducedtumorgrowthbutimproved...
