����������������TheJournalofClinicalInvestigationhttp://www.jci.orgVolume120Number2February2010�������������������������������������������������������������������������������������������������������������������������������������������������������������������FannyChalmin,1,2,3SylvainLadoire,1,2,3,4GrégoireMignot,1,2JulieVincent,1,2,3MélanieBruchard,1,2,3Jean-PaulRemy-Martin,5WilfridBoireau,6AlainRouleau,6BenoitSimon,6DavidLanneau,1,3AurélieDeThonel,1,3GabrieleMulthoff,7ArletteHamman,1FrançoisMartin,1,2,3BrunoChauffert,1,2,3,4EricSolary,1,3LaurenceZitvogel,8CarmenGarrido,1,3BernhardRyffel,9ChristopheBorg,5LionelApetoh,10CédricRébé,1,2,3,4andFrançoisGhiringhelli1,2,3,41INSERMU866,Dijon,France.2INSERMAVENIRTeam,Dijon,France.3FacultyofMedicineandPharmacy,UniversityofBurgundy,Dijon,France.4Anti-CancerCentreGeorgesFrançoisLeclerc,Dijon,France.5INSERMU645,EFSBourgogne-FrancheComté,UniversityofFranche-Comté,Besançon,France.6FEMTO-STInstitute,UniversityofFrancheComté,Besançon,France.7DepartmentofRadiationOncology,UniversityHospital,KlinikumrechtsderIsar,TechnischeUniversitätMünchen,Munich,Germany.8INSERMU805,InstitutGustaveRoussy,Villejuif,France.9LaboratoryofMolecularImmunologyandEmbryology,CNRSUMR6218,Orléans,France.10CenterforNeurologicDiseases,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,Massachusetts,USA.Myeloid-derivedsuppressorcells(MDSCs)havebeenidentifiedinhumansandmiceasapopulationofimma-turemyeloidcellswiththeabilitytosuppressTcellactivation.Theyaccumulateintumor-bearingmiceandhumansandhavebeenshowntocontributetocancerdevelopment.Here,wehaveisolatedtumor-derivedexo-somes(TDEs)frommousecelllinesandshownthataninteractionbetweenTDE-associatedHsp72andMDSCsdeterminesthesuppressiveactivityoftheMDSCsviaactivationofStat3.Inaddition,tumor-derivedsolublefactorstriggered...
