Oxidative stress-A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease.pdfVIP免费

AcceptedManuscriptTitle:Oxidativestress:AmajorpathogenesisandpotentialtherapeutictargetofantioxidativeagentsinParkinson’sdiseaseandAlzheimer’sdiseaseAuthor:TianfangJiangQianSunShengdiChenPII:S0301-0082(15)30007-1DOI:http://dx.doi.org/doi:10.1016/j.pneurobio.2016.07.005Reference:PRONEU1468Toappearin:ProgressinNeurobiologyReceiveddate:16-4-2015Reviseddate:19-6-2016Accepteddate:11-7-2016Pleasecitethisarticleas:Jiang,Tianfang,Sun,Qian,Chen,Shengdi,Oxidativestress:AmajorpathogenesisandpotentialtherapeutictargetofantioxidativeagentsinParkinson’sdiseaseandAlzheimer’sdisease.ProgressinNeurobiologyhttp://dx.doi.org/10.1016/j.pneurobio.2016.07.005ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.1Oxidativestress:amajorpathogenesisandpotentialtherapeutictargetofantioxidativeagentsinParkinson’sdiseaseandAlzheimer’sdiseaseTianfangJianga,QianSuna,ShengdiChena,b,*aDepartmentofNeurology,InstituteofNeurologyandtheCollaborativeInnovationCenterforBrainScience,RuiJinHospitalAffiliatedtoShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai200025,ChinabLaboratoryofNeurodegenerativeDiseases,InstituteofHealthScience,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofScience&ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai200025,China*CorrespondingauthorTel.:021-6445-4473E-mailaddress:chen_sd@medmail.com.cn2Highlights:1.Wepresentevidence,gatheredoverthelastdecade,concerningavarietyofpathogenicproteins,theirsignalingpathwaysandpathogenicmechanismsassociatedwithoxidativestressinParkinson’sdiseaseandAlzheimer’sdisease.2.Wealsoalsoemphasizeantioxidativeoptions,includingsomenewneuroprotectiveagentsthateliminateexcessreactiveoxygenspeciesefficient...