Seeonlineversionforlegendandreferences.986Cell142,September17,2010©2010ElsevierInc.DOI10.1016/j.cell.2010.08.041SnapShot:NuclearReceptorsIINeilJ.McKennaandBertW.O’MalleyBaylorCollegeofMedicine,Houston,TX77030,USAReceptororFamily*SymbolsExpressionMajorFunctionsDiseaseAssociationsTargetGenesEstrogen-relatedreceptors*ERRα/NR3B1;ERRβ/NR3B2;ERRγ/NR3B3Allmajorsystemswithspecificisoformsshowingpeaksofexpressioninmetabolictissues(ERRαandERRβ)andtheCNS(ERRγ)Structurallyhomologoustoestrogenreceptors;bindEREsbutnotactivatedbyestrogens;modulatetheexpressionofenzymesinvolvedinadipogenesis,energymetabolism,andsynthesisoflipids,eicosanoids,andsteroidsBone,metabolic,deafness↑VEGF,PDK4,PLIN1,RB1CC1,BSP,CYP11A1,CYP27A1,HK2,PLSCR2,VLDLR,TFF1(ERRα);CDKN1A(ERRβ);HK2,PLSCR2,VLDLR,CYP27A1,CDKN1A,CDKN1B,PDK4(ERRγ)Steroidogenicfactor-1SF-1/NR5A1Adrenalgland,hypothalamus,ovaries,andtestesRegulatesmammaliansexualdevelopment;controlsdifferentiationofsteroidogenictissuesEndocrine,metabolic↑STAR,CYP11A1,HS3DB2,INHA,AMH,CYP19A1Retinoicacidreceptor-relatedorphanreceptors*RORα/NR1F1;RORβ/NR1F2;RORγ/NR1F3Manysystemswithpeaksinthebrain,testis,andskeletalmuscle(RORα);GItract,metabolic,andimmunesystems(RORγ);CNS(RORβ)RORαandRORβhaverolesincircadianrhythmandcellsurvival;RORγisinvolvedinthymocytedevelopmentandhomeostasis;melatoninactivatesRORαNA↑IL6,IL17A,CYP19A1,CYP7B1,SREBF1,APOC3,ARNTL1,CLOCK,CRY1,NPAS2,FGB,REV-ERBA,AFP,SULT1E1(RORα);ARNTL1(RORβ);ARNTL1(RORγ);↓OCN(RORα)Hepatocytenuclearfactor4receptors*HNF4α/NR2A1;HNF4β/NR2A2;HNF4γ/NR2A3PeaksintheGItract,WAT,andpancreas(HNF4α);GItractandCNS(HNF4γ);liver,kidney,stomach,intestine,lung,ovaries,andtestis(HNF4β)Requiredforestablishingandmaintaininghepatocytedifferentiation.HNF4αconstitutivelybindsfattyacidsMetabolic↑LPIN1,SLC25A20,ABCC6,LIPC,COPA,HDAC6,RBKS,ERBB3,NGEF,ANXA4,LEAP2,EPO,G6PC(HNF4α)Growthfactor-inducibleimmediateearlygenenur/77-likereceptorNur77/NR4A1Allmajorsystemswithpeaksintheaorta,adrenalgland,olfac...
