Fas[CD95]6FasL[CD95L;CD178]TRAIL-R1[DR4;CD261]10ATRAIL[Apo-2L;CD253]10TNF-R1[CD120a]1ATNF-α1LTα[TNF-β]2TNF-R2[CD120b]1BTRAIL-R2[DR5;CD262]10BTRAIL-R3[DcR1;CD263]TRAIL-R4[DcR2;CD264]10D6DR3[TRAMP]12CD137[4-1BB]9OX40[CD134]4CD30[Ki-1]8CD27GITR[AITR;CD357]18BCMA[CD269]1715TL1A[VEGI]HVEM[CD270]14OPGRANK[CD265]11BBTLA[CD272]11RANKL[TRANCE;CD254]DcR36B14LIGHT[CD258]12TWEAKCD405TACI[CD267]13BBAFF-R[BR3;CD268]13CXEDAR27EDARNGFR[p75;CD271]167IGFLR1[TMEM149]11A3LTβ[LTα1β2]LTβR7CD27L[CD70]8CD30L[CD153]5CD40L[CD154]9CD137L[4-1BBL]4OX40L[CD134L;CD252]18GITRL[AITRL;TL6]13APRIL[CD256]13B20BAFF[BLyS;THANK;CD257]EDA-A2EDA-A1RELT19LTROY[TAJ]19??NGFIGFLsTRAF1bindingTRAF2bindingTRAF3bindingTRAF4bindingTRAF5bindingTRAF6bindingDeathdomain1016MatrilysinMetalloproteinase(TACE)FurinTNFSFnumberTNFRSFnumberGPiInhibition10CDR6[CD358]21N-APPDeathdomaintruncatedFn14[TWEAK-R;CD266]12ATNFhomologydomain(THD)Cysteinerichdomain(CRD)3TNFSuperfamilyLigands&Receptorswww.adipogen.comAdipogenInternationalSchützenstrasse12�CH-4410Liestal�SwitzerlandTEL:+41-61-926-60-40�FAX:+41-61-926-60-49E-Mail:info@adipogen.com�www.adipogen.comJUL2013SPECIESCROSS-REACTIVITIESTNFLIGANDSLIGANDSTRAIL[Apo-L2]FasL[CD95L]TNF-�LT�[TNF-�]TL1A[VEGI]TWEAKLIGHTLT��[LT�1�]BTLARANKL[TRANCE]CD27L[CD70]CD30L[CD153]CD40L[CD154]CD137L[4-1BBL]OX40L[CD134L]GITRL[AITRL]APRILBAFFEDA-A2EDA-A1NGFN-APPIGFLshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumshumsTNFRECEPTORSTRAIL-R1[DR4]hu✔✔––––––––––––––––––––––––––––––––––––––––––––TRAIL-R2[DR5]hu✔✔––––––––––––––––––––––––––––––––––––––––––––ms✔✔––––––––––––––––––––––––––––––––––––––––––––TRAIL-R3[DcR1]DcTRAIL-R1hu✔✔––––––––––––––––––––––––––––––––––––––––––––ms–±––––––––––––––––––––––––––––––––––––––––––––TRAI...
