CellSignalingTechnology©2003–2018CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationTranscriptionalInhibitoryModificationPathwayDiagramKeyTumorAngiogenesisPhospholipidSignalingPWrev.08/02/18EphrinAngiopoietin1KeybFGFAngiopoietin2PDGFSLITVEGF4E-BP1Ets2HIF-1αHIF-1αHIF-1αHIF-1αHIF-1βHIF-1βPHDsCBP/p300MMPsMMPsPDGFRTie2VEGFR2FGFRIntegrinsNeuropilinStat3TargetGenesTargetGenesHRENormoxiaHypoxiaPrecursorEndothelialCellPlateletTipCellPericyteEndothelialCellBasementMembraneTumorAssociatedMacrophage(TAM)elF4E1Erk1/2AktOHOHNucleusTumorCellTumorCellTie2EPHROBO1/2ROBO3Integrins•GrowthFactors•Cytokines•ECMProteases•GrowthFactors•Cytokines•ECMProteasesTumorAngiogenesisrev.08/02/18
