KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysEndosomeMD-2TRAMTRIFTIRAPMyD88TIRAPMyD88TIRAPMyD88MyD88MyD88IRAK-4IRAK-MIRAK-1IRAK-2TLR4TLR4CD14TLR5TLR5TLR11TLR11TLR1TLR2TLR6TLR2IKKβIKKεTBK1IKKγ/NEMOIKKαIκBαubMyD88TLR9TLR9MyD88MyD88TLR7TLR8TLR3TLR3TRIFp65/RelANF-κBIRF-7IRF-7IRF-3IRF-3ECSITA20TOLLIPRIP1RIG-IMAVSTRAF3ST2LSOCS1TRIAD3ATAK1TAB1/2JNKp38MAPKMKK3/6MKK4/7FADDCasp-8MEKK-1TRAF6Ubc13UEV1ALPSCpGdsRNAdsRNAor5'-triphosphateRNAATPFlagellinUropathogenicBacteria,ProfilinDiacylLipopeptideTriacylLipopeptideProteasomalDegradationApoptosisTranscriptionFactorsInflammation,ImmuneRegulation,Survival,ProliferationNucleusAnti-viralCompounds,ssRNAAnti-viralCompounds,ssRNACytoplasmToll-likeReceptorSignaling©2006–2014CellSignalingTechnology,Inc.
