172Cell143,October1,2010©2010ElsevierInc.DOI10.1016/j.cell.2010.09.032SnapShot:NRCoregulatorsNeilJ.McKennaandBertW.O’MalleyBaylorCollegeofMedicine,Houston,TX77030,USACoregulator/Family*SymbolsInteractions(NuclearReceptors)FunctionsDiseaseLinksInteractions(Coregulators)Interactions(Others)Steroidreceptorcoactivators*SRC-1/NCOA1;SRC-2/NCOA2;(GRIP1,TIF2);SRC-3/NCOA3;(AIB1,ACTR,TRAM-1,RAC3)SRC-1AR,COUP-TFI,CAR,ERα,ERβ,ERRg,FXRα,GR,HNF4α,PPARα,PPARg,PXR,PR,RORβ,RARα,RARβ,RXRα,RXRβ,SF-1,TRα,TRβ,EARCoactivatorsfortheNRsuperfamilyandothertranscriptionfactors;rolesinreproductivedevelopmentandmetabolism.Domains:PAS/bHLH,acetyltransferaseUp-regulatedincancerSRC-1ASC-1,ANCO-1,BCL-3,BAF57.BRG1,CBP,CyclinD1,p300,GRIP1,NCoR,PGC-1,p72,PRMT1,PRMT2,14-3-3η,P/CAFSRC-1AHR,ARNT,FOS,HIF1A,FOXA2,JUN,CIITA,NFKB1,SRF,STAT6,TEAD1,TITF1,YWHAQSRC-2AR,ERα,ERRβ,LRH1,GR,HNF4α,PPARg,RORα.RARα,RXRα,SF1,TRβ,VDRSRC-2ANCO-1,BAF57,BRCA1,CARM1,p300,GMEB-1,PRMT1,SRC-1,14-3-3ηSRC-2AHR,ARNT,CCNT1,MAGEA11,TITF1,PPFIA1,SRCAP,tatSRC-3AR,COUP-TFI,ERα,ERβ,ERR-β,LRH-1,GR,PPARα,PXR,RARα,RXRα,RXRβ,TRβ,VDR,Nur77SRC-3ANCO-1,BAF57,BRCA1,CBP,CARM1,CyclinD1,p300,MMS19,P/CAF,PRMT1,PIAS1,TBP,14-3-3ηSRC-3BMP6,BMP7,E2F1,ERBB2,ETS1,ETS2,ETV1,GSK3B,IKBKB,MYC,NPAS2,EBAG9,YWHAQ,SUFUPeroxisomeproliferatorreceptorgcoactivator1PGC-1/PPARGC1ACAR,ERα,ERRg,FXRα,GR,HNF4α,LXRα,PPARα,PPARg,RXRα,TRβCriticalrolesinfatandcarbohydratemetabolismandenergyhomeostasis.Domain:RNP-1Metabolic,cardiovascularFKHR,Sirt1,SRC-1,TRAP230,TRAP220,DRIP150HCFC1,NRF1,USF2,SURB7,TRFP,G6PC,PCK1NuclearreceptorcorepressorN-CoR/NCOR1AR,ERα,GCNF,GR,PPARα,PPARg,PPARd,RARα,REVERBα,REVERBβCorepressorfortheNRsuperfamilyandothertranscriptionfactors;recruitshistonedeacetylases.Domain:SANTUp-regulatedincancerGPS2,HDAC3,HDAC4,TBLR1,PTα,Sin3A,SHARP,SMRT,SAP30,Sirt1,SF3A1,TBL1,TIF1βBCL6,RUNX1T1,CBFA2T3,CCND2,CDKN2A,CHD1,CLK1,DACH1,ERBB2,ETS1,ETS2,HD,HSPA4,CD82,KIF11,MECP2,MYOD1,NFKB1,PDCD2,PHB,PML,CCL3,SKI,SMARCB1,SMARCC1,SM...
