CRNDELincRNA-p21GLUTMCT4UCA1miR-155miR-124miR-133bmiR-122miR-378/378*miR-370AdipocytesPERIPHERALMETABOLICTISSUEHEPATOCYTEFattyacidelongationInsulinsecretionmiR-33a/bGLYCOLYSISmiR-33amiR-375VDCCmiR-7miR-143miR-103/107miR-33a/bGlucagonreleaseLeptinRGLP1RInsRInsRInsInsRIGF1RmiR-141/200DLK1-MEG3miRNAsApoptosisLipidraftsLnc-HCmiR-122ABCA1miR-122miR-103miR-107miR-181amiR-183FattyacidsynthesismiR-34a/cmiR-369-3pmiR-374amiR-4524a/bNRCPlet-7let-7let-7IVIVIIIIILincRNA-p21miR-124Lin28a/bmiR-199amiR-143MCT1miR-93miR-133miR-223miR-195-5pmiR-144PCGEM1PentosephosphatepathwayInsulinsignalingNucleotidebiosynthesisNBR2NBR2miR-181cmiR-210miR-23a/bNucleotidebiosynthesisUCA1CCAT2GlucosemetabolismLipidmetabolismInsulinandglucaconmetabolismAc-CoACitrateIsocitrateSuccinyl-CoASuccinateFumarateMalateOxaloacetateTCAcycleInsInsInsInsInsInsLEGENDHK2PKM2LDHPDHIDHGLSGLS2IDHmutPDK1FACSCPT1FASACCHMGCRAKTPI3KORPB8AKTAKTp53TP53INP1IRSsIRSsR5PPEPPyruvatePyruvatePyruvateGlutamineGlutamate2HGFattyacidsFattyacyl-CoAPalmitateAcylcarnitineAc-CoAHMG-CoAMalonyl-CoATGTGGLP-1LactateTCAcycleIGF-1LLLLCCLLLLGPGGGGAc-CoAPEPPyruvateGPGCa+Ca+Ca+Ca+Ca+Ca+LactateGlucoseTriglyceridesCholesterolInsulinCalciumGlutaminemetabolismandTCAcycleDirectinhibitionIndirectinhibitionDirectactivationIndirectactivationDYNLRB2-2AMPKAMPKSeeonlineversionforlegendandreferences.220CellMetabolism25,January10,2017©2017ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cmet.2016.12.012SnapShot:Non-codingRNAsandMetabolismRoxanaSimonaRedis1,2andGeorgeAdrianCalin11DepartmentsofExperimentalTherapeuticsandLeukemiaandtheCenterforRNAInterferenceandNon-codingRNA,UniversityofTexasM.D.AndersonCancerCenter,Houston,TX77030,USA;2ProQRTherapeuticsN.V.,2333CKLeiden,theNetherlands220.e1CellMetabolism25,January10,2017©2017ElsevierInc.DOIhttp://dx.doi.org/10.1016/j.cmet.2016.12.012SnapShot:Non-codingRNAsandMetabolismRoxanaSimonaRedis1,2andGeorgeAdrianCalin11DepartmentsofExperimentalTherapeuticsandLeukemiaandtheCenterforRNAInterferenceandNon-codingRNA,Universityo...
