LPSFlagellinNF-κBTIRAPMyD88TLR4TLR1TLR2TLR6TLR5TIRAPMyD88CD14NucleusCaspase-1ActivationCaspase-1(Caspase-5)pro-IL-1βIL-18(secreted)IL-1β(secreted)pro-IL-18InflammasomesNLRP1,NLRP3,NLRP6,NLRC4,RIG-I,AIM2AscDNASensorsRNApolyIIIDAIMRE11LRRFIP1DDX41IFI16AIM2DHX9/36Toll-likeReceptorsRIG-I-likeReceptorsCARD9Bcl-10MALT1NOD-likeReceptorsCytosolicDNASensorsRNApolyIIIdsDNA(ViralInfection,Bacteria)InflammatoryResponsePAMPs/DAMPsIRF3IRF7AP1Inflammation,ImmuneRegulation,Autophagy,Survival,Proliferation,Apoptosis,Necrosis/NecroptosisTranscriptionMD2BacterialCellWallCompoundsLipopeptidesLipoglycansPeptidoglycansSTINGβ-CateninTypeIIFNsPro-inflammatoryCytokines&ChemokinesCytoplasmRAGEHeparansulfateHMGB1TRAMTRIFMyD88TRIFIRF3IRF7NF-κBAP1RIP1TRADDMAPKp38RascGAScGAMPPKReIF-2αPProteinSynthesisMAVSBcl-10CARD9MitochondriaERViraldsRNAATP+GTPTLR10MyD88TLR11TLR12ProfilinNIKTIRAPMyD88TRIFMAPKRaf-1Horseshoe-shapedsolenoidN-terminalextracellularleucine-richrepeat(LRR)motifsCompactandglobularC-terminalintracellularToll/interleukin-1receptor(TIR)domainActivationTranslocationTLRsInhibitionTLR11/TLR12:Expressedinmiceonly?RIP2CARD9Nod2MDPNod1iE-DAPMAPKp38JNKS100A8/A9C-typeLectinReceptorsSykDectin-1Dectin-2MincleSykFcRγSAP130α-MannoseCordFactorFungalHyphaeN-linkedMannanDC-SIGNN-linkedMannanVirusesMycobacteriaZymosanβ-GlucanPKCδRNASensorsRIG-IMDA5LGP2LSm14AViralRNAViralInfection+TranslocationTLR4TLR3TLR7/8TLR9EndosomedsRNAssRNACpGDNAODNsCD14()4PatternRecognitionReceptors(PRRs)SignalingPathwayswww.adipogen.comAdipogenInternationalSchützenstrasse12•CH-4410Liestal•SwitzerlandTEL:+41-61-926-60-40•FAX:+41-61-926-60-49E-Mail:info@adipogen.com•www.adipogen.comNOV2013
