CellSignalingTechnology©2003–2018CellSignalingTechnology,Inc.www.cellsignal.comNeuronalandGlialCellMarkerAtlasPathwayDiagramKeyDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationTranscriptionalInhibitoryModificationPathwayDiagramKeyOligodendrocytesNeuroepithelialCells*NeuralStemCellMarkers-Musashi-Notch1-SSEA1-E-Cadherin-HES1-NestinProliferatingCellMarkers:-BrdU-Ki-67-PCNASchwannCellsGlutamatergicNeuronsAlzheimer’sDiseaseParkinson’sDiseaseALSGABAergicNeuronsDopaminergicNeuronsSerotonergicNeuronsCholinergicNeuronsInterneuronsMotorNeuronsAstrocytesMatureNeuronsIntermediateProgenitors*-EAAT1(GLAST-1)-EAAT2(GLT-1)-GAP43-GFAP-A2B5-CNPase-MAG-MOG-A2B5-ALDH1L1-EAAT1(GLAST-1)-EAAT2(GLT-1)-GFAP-Notch-S100B-EOMES(Tbr2)-Neurogenin2-Pax6CellTypeMarkersNeurodegenerativeDisease-AssociatedMarkersImmatureNeuronsNeurotransmittersNeuronalSubtypes-Doublecortin-NeuroD1-TBR1-β3-Tubulin-MyelinBasicProtein-NCAM-p75NTR-S100BRadialGlia*Microglia-BLP(FABP7)-N-Cadherin-GFAP-EAAT1(GLAST-1)-ASC-CD11b(ITGAM)-CD40-CD45-CD68Homeostatic:-C1qA/B-CX3CR1-Cystatin3(CST3)-P2RY12Stage1Upregulated-ApoE-DAP12(TYROBP)-TREM2FunctionalMarkers:-Arg3.1(Arc)-CaMKII-CREB-EGR1-Erk-c-Fos-PKA*ProliferatingCellsStage2(TREM2-Dependant)-Axl-CystatinF(CST7)-Nestin-Sox2-TenascinC-Vimentin-MyelinBasicProtein-NG2-Olig2-SOX10-VGLUT1/2-ChAT-Calbindin-Calretinin-5-HT3AReceptor-ChAT-HB9-Islet-1/2-ADORA2A-DARPP-32-GAD1/2-β-Amyloid(Aβ)-ApoE-CD33-Presenilin1/2(PSEN1/2)-Tau-TREM2-DJ-1-GBA-LRRK2-Parkin-PINK1-α-Synuclein-UCHL1-VPS35-C9orf72-FUS-SOD1-SQSTM1-TDP43-NeuropeptideY-Penk-ALDH1A1-FoxA2-GIRK2-FEV-SERT-TPH2-TryptophanHydroxylase-Lmx1B-TyrosineHydroxylase-MAP2-NeuN-Neurofilament-H-Neurofilament-L-Neurofilament-M-Parvalbumin-Somatostatin-VIP-Neurogenin2-Olig2-Notch1-Sox2-Sox10-NeuronSpecificEnolase(NSE)-Tau-Thy1-β3-Tubulin-UCHL1Downregulated-P2RY12-CX3CR1-TMEM119-CD33-Dectin-1(CLEC7a)-CD11c(ITGAX)-Spp1-F4/80-Iba1-PU.1-TMEM119Disease-AssociatedMicroglia(DAM)rev.06/18
