1867ChengWY,etal.Gut2020;69:1867–1876.doi:10.1136/gutjnl-2020-321153RecentadvancesinbasicscienceTheroleofgutmicrobiotaincancertreatment:friendorfoe?WingYinCheng,1Chun-YingWu,2JunYu1Tocite:ChengWY,WuC-Y,YuJ.Gut2020;69:1867–1876.►Additionalmaterialispublishedonlineonly.Toviewpleasevisitthejournalonline(http://dx.doi.org/10.1136/gutjnl-2020-321153).1StateKeyLaboratoryofDigestiveDisease,InstituteofDigestiveDiseaseandTheDepartmentofMedicineandTherapeutics,LiKaShingInstituteofHealthSciences,CUHKShenzhenResearchInstitute,TheChineseUniversityofHongKong,HongKongSAR,China2DivisionofTranslationalResearch,DepartmentofMedicalResearch,TaipeiVeteransGeneralHospital,Taipei,Taiwan;InstituteofBiomedicalBioinformaticsandSchoolofMedicine,NationalYang-MingUniversity,Taipei,Taiwan;CollegeofPublicHealthandGraduateInstituteofClinicalMedicine,ChinaMedicalUniversity,Taichung,TaiwanCorrespondencetoDrJunYu,InstituteofDigestiveDiseaseandTheDepartmentofMedicineandTherapeutics,ChineseUniversityofHongKong,NewTerritories,HongKong;junyu@cuhk.edu.hkReceived18March2020Revised2July2020Accepted6July2020PublishedOnlineFirst5August2020©Author(s)(ortheiremployer(s))2020.Re-usepermittedunderCCBY-NC.Nocommercialre-use.Seerightsandpermissions.PublishedbyBMJ.ABSTRACTThegutmicrobiotahasbeenimplicatedincancerandshowntomodulateanticancerdrugefficacy.Alteredgutmicrobiotaisassociatedwithresistancetochemodrugsorimmunecheckpointinhibitors(ICIs),whereassupplementationofdistinctbacterialspeciesrestoresresponsestotheanticancerdrugs.Accumulatingevidencehasrevealedthepotentialofmodulatingthegutmicrobiotatoenhancetheefficacyofanticancerdrugs.Regardlessofthevaluablefindingsbypreclinicalmodelsandclinicaldataofpatientswithcancer,amorethoroughunderstandingoftheinteractionsofthemicrobiotawithcancertherapyhelpsresearchersidentifynovelstrategyforcancerprevention,stratifypatientsformoreeffectivetreatmentandreducetreatmentcomplication.Inthisreview,wediscussthescientificevidenceontheroleofgutmicrobiotaincancertreatment,andhig...
