KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysSrcDynamincPLA2SynapsinsTHJNK3Src-likePLCβGRK2β-ArrestinSrcCaMKII,-IVPLCβRGSRGSRACK1β-Arrestin1MEKErkc-RafRasGEFSOSRasGAPRasGRPRasGRFSynGAPEPACMPGαsGTPGαqGTPACGiβγMAPKAPK2MSK1/2p90RSKp90RSKErk1/2Erk1/2MKP-3cdc25MEK1/2KSRB-RafPKAc-RafPKCPKCSrcSrcPYK2PI3KγFAKGRB2RasRap1IMPFoxO3C-TAK1B-Rafc-RafHeterodimerIntegrinsGs-CoupledReceptorGq-CoupledReceptorGi-CoupledReceptorRTKsCatecholaminesFocalAdhesionsNucleusCytoplasm[Ca2+][cAMP]IP3ReceptorInternalizationendosomeH+TranscriptionTumorigenesisProgressionofCellCyclep90RSKErk1/2PEA-15GProtein-coupledReceptorsSignalingtoMAPK/Erk©2002–2014CellSignalingTechnology,Inc.
