������������������Thedoublelifeofcardiacmesenchymalcells:EpimetabolicsensorsandtherapeuticassetsforheartregenerationChiaraCencioni,SandraAtlante,MatteoSavoia,FabioMartelli,An-tonellaFarsetti,MaurizioC.Capogrossi,AndreasM.Zeiher,CarloGaetano,FrancescoSpallottaPII:S0163-7258(16)30183-8DOI:doi:10.1016/j.pharmthera.2016.10.005Reference:JPT6969Toappearin:PharmacologyandTherapeuticsPleasecitethisarticleas:Cencioni,C.,Atlante,S.,Savoia,M.,Martelli,F.,Farsetti,A.,Capogrossi,M.C.,Zeiher,A.M.,Gaetano,C.&Spallotta,F.,Thedoublelifeofcardiacmesenchymalcells:Epimetabolicsensorsandtherapeuticassetsforheartregeneration,PharmacologyandTherapeutics(2016),doi:10.1016/j.pharmthera.2016.10.005ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCEPTEDMANUSCRIPTACCEPTEDMANUSCRIPTP&TReview22986Thedoublelifeofcardiacmesenchymalcells:epimetabolicsensorsandtherapeuticassetsforheartregenerationChiaraCencioni1,6,SandraAtlante1,6,MatteoSavoia1,2,6,FabioMartelli3,AntonellaFarsetti4,6,MaurizioC.Capogrossi5,AndreasM.Zeiher6,CarloGaetano1,6,*,andFrancescoSpallotta1,61DivisionofCardiovascularEpigenetics,DepartmentofCardiology,GoetheUniversity,FrankfurtamMain60596,Germany;E-Mails:chcencioni@gmail.com(C.C.);sandra.atlas@yahoo.it(S.A.);savomat88@gmail.com(M.S.);fspallotta@gmail.com(F.S.)2UniversitáCattolica,InstituteofMedicalPathology,00138Rome,Italy3MolecularCardiologyLaboratory,IRCCS-PoliclinicoSanDonato,SanDonatoMilanese,Milan20097,Italy;E-Mail:fabio.martelli@grupposandonato.it4ConsiglioNazionaledelleRicerche,IstitutodiBiologiaCellulareeNeurobiologia,Roma,Italy;E-Mail:afarsetti@gmail.com5LaboratoriodiPatologiaVascolare,IstitutoDermopaticodell’Im...