162Cell145,April1,2011©2011ElsevierInc.DOI10.1016/j.cell.2011.03.029Seeonlineversionforlegendandreferences.SnapShot:TheEpithelial-MesenchymalTransitionJonathanP.Sleeman3,4andJeanPaulThiery2,31IMCBandExperimentalTherapeuticsCentre,BiopolisA*STAR,138673Singapore;2CancerScienceInstitute,117456Singapore3UniversityofHeidelberg,MedicalFacultyMannheim,D-68167Mannheim,Germany;4KarlsruheInstituteofTechnology,Postfach3640,76021Karlsruhe,GermanyLaminin5TβRITβRITβRIISnail1/2Zeb1/2Par3Par6aPKCBMPsBMPR1BMPR2PatchedGrowthfactorsIL-6JAG2JAMp120-Catp53RhoACdc42RhoARhoAPDGFCdc42Cdc42Glu-tubulinRac1Par6Par3aPKCClaudinJAMOccludinClaudinOccludinZO3ZO1ZO2ActinIQGAPE-cadherinNectinβ-catβ-catβ-catβ-catβ-catβ-catAfadinF-actinVinculinXα-ActininClip170Dynein/dynactincomplexmiR-200FOXA1/2BASEMENTMEMBRANEROCKDDR1Collectivecellmigrationp190RhoGAPDAP21PGSK3βRhoARhoEMyosinlightchainHIF1/2LoxL2E2.2KLF8FOXQ1E47GSCTwistSnail1/2Snail1/2Smad2/3HedgehogERPAK1STAT3IL-6RPI3KRasRTKLIV1AKTMAPKNF-κBNF-κBCSLGli1MTA3Zeb1/2miR-205miR-200miR-205E-cadherinandotherdownregulatedgenes(seeboxA)Upregulatedgenes(seeboxB)E-cadherinDesmosomeCytokeratinGapjunctionPlakoglobinDesmoplakinBalancedactivitiesTightjunctionEPITHELIALMESENCHYMALMESENCHYMALAdherensjunctionStabilizedactincytoskeletonApicobasalmicrotubulesp120-Catp120-CatKaisop120-Catp120-CatGSK3βDishevelledLRP5/6FrizzledNectinAfadinRTKDDR1Collagen1MMPsNCAMN-cadPDGFRTranscriptionFocaladhesionformationAdherensjunctiondisassemblyFilopodiaLamellipodiaMigrationInvasionECMremodellingFocaladhesionassemblyandturnoverExamplesofup-regulatedgenesTβRIVimentinSMAN-cadherinNCAMFibronectinLamininsmiR-661MMPsExamplesofdown-regulatedgenesTubulintyrosineligaseClaudinsOccludinsZO1/ZO3Crumbs3DesmoplakinConnexin43E-cadherinNectin-1VE-cadherinCytokeratinsCollagenI,IIOtherEMT-associatedeffectsResistancetosenescenceResistancetoapoptosisTherapyresistanceStemnessCytoskeletonremodelingMembraneruffesLossofdesmosomesMicrotentaclesDissociationoftightjunctionsLossofgapjunctions...
