ContentslistsavailableatScienceDirectSeminarsinImmunologyjournalhomepage:www.elsevier.com/locate/ysmimTheepigeneticsofinflammaging:Thecontributionofage-relatedheterochromatinlossandlocus-specificremodellingandthemodulationbyenvironmentalstimuliChristineNardinia,b,c,Jean-FrancoisMoreaud,e,NoémieGensousf,FrancescoRavaiolif,PaoloGaragnanif,g,h,i,j,⁎⁎,MariaGiuliaBacalinik,⁎aDepartmentofLaboratoryMedicine,KarolinskaInstitutet,Stockholm,SwedenbCNRIAC“MauroPicone”,Roma,ItalycPersonalGenomicsS.r.l.,Verona,ItalydUniversityofBordeaux,CNRS-UMR5164,146rueLéoSaignat,33076Bordeaux,FranceeCHUBordeaux,PlaceAmélieRaba-Léon,Bordeaux,FrancefDepartmentofExperimental,DiagnosticandSpecialtyMedicine(DIMES),UniversityofBologna,Bologna,ItalygClinicalChemistry,DepartmentofLaboratoryMedicine,KarolinskaInstitutetatHuddingeUniversityHospital,Stockholm,SwedenhLaboratoryofCellBiology,RizzoliOrthopaedicInstitute,Bologna,ItalyiCNRInstituteofMolecularGenetics,UnitofBologna,Bologna,ItalyjCenterforAppliedBiomedicalResearch(CRBA),St.Orsola-MalpighiUniversityHospital,Bologna,ItalykIRCCSIstitutodelleScienzeNeurologichediBologna,Bologna,ItaliaARTICLEINFOKeywords:EpigeneticsHistonesMethylationInflammagingABSTRACTAgrowingamountofevidencesindicatesthatinflammaging–thechronic,lowgradeinflammationstatecharacteristicoftheelderly–istheresultofgeneticaswellasenvironmentalorstochasticfactors.Someofthese,suchastheaccumulationofsenescentcellsthatarepersistentduringagingoraccompanyitsprogression,seemtobesufficienttoinitiatetheagingprocessandtofuelit.Others,likeexposuretoenvironmentalcompoundsorinfections,aretemporaryandresolvewithina(relatively)shorttime.Inbothcases,however,acellularmemoryoftheeventcanbeestablishedbymeansofepigeneticmodulationofthegenome.Inthisreviewwewillspecificallydiscusstherelationshipbetweenepigeneticsandinflammaging.Inparti-cular,wewillshowhowage-associatedepigeneticmodificationsconcernedwithheterochromatinlossandgene-specificremodelling,canpromoteinflammaging.Furthermore,wewillre...
