KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysUbUbUbUbUbUbUbUbUbE1E2E1E2E2E3DUBE3ProteinSubstrateATPAMP26SProteasomePeptidesADPATPProteinSubstrateMultipleCyclesProteinSubstrateProteinSubstrate19S20S19SE3UbiquitinLigasesc-CblN-Terminalc-Cbl(906aa)RINGUBAEFEFβ-TrCP(605aa)WDDomainsF-boxSkp2(424aa)F-boxLRRRepeatsNEDD4(1319aa)WWDomainsHECTUbiquitin/Proteasome©2004–2014CellSignalingTechnology,Inc.
