TRPActivatorsInhibitorsPutativeInteractingProteinsProposedFunctionsC1ActivationpotentiatedbyPLCpathwaysGd,LaTRPC4,TRPC5,calmodulin,TRPC3,TRPP1,IP3Rs,caveolin-1,PMCAHomodimerisapurportedstretch-sensitiveionchannel;formheteromericionchannelswithTRPC4orTRPC5inneuronsC2Pheromonereceptormechanism?Calmodulin,IP3R3,Enkurin,TRPC6TRPC2-/-micerespondabnormallytourine-basedolfactorycues;pheromonesensingC3Diacylglycerol,[Ca2+]I,activationpotentiatedbyPLCpathwaysBTP2,flufenamate,Gd,LaTRPC1,calmodulin,PLCβ,PLCγ,IP3R,RyR,SERCA,caveolin-1,αSNAP,NCX1PotentialroleinvasoregulationandairwayregulationC4La(100µM),calmidazolium,activationpotentiatedbyPLCpathways[Ca2+]i,2-APB,niflumicacid,DIDS,La(mM)TRPC1,TRPC5,calmodulin,PLCβ,NHERF1,IP3RTRPC4-/-micehaveabnormalitiesinendothelial-basedvesselpermeabilityC5La(100µM),activationpotentiatedbyPLCpathways,nitricoxide2-APB,flufenamate,La(mM)TRPC1,TRPC4,calmodulin,PLCβ,NHERF1/2,ZO-1,IP3RNophenotypeyetreportedinTRPC5-/-mice;potentiallyregulatesgrowthconesandneuriteextensionC6Diacylglycerol,[Ca2+]I,20-HETE,activationpotentiatedbyPLCpathways2-APB,amiloride,Cd,La,GdCalmodulin,TRPC3,TRPC7,FKBP12Missensemutationinhumanfocalsegmentalglomerulo-sclerosis(FSGS);abnormalvasoregulationinTRPC6-/-mice,proposedroleinATII-inducedcardiachypertrophyC7Diacylglycerol,activationpotentiatedbyPLCpathways[Ca2+]I,flufenamate,LaCalmodulin,TRPC3,TRPC6,FKBP12,MxA,TRPC1NophenotypeyetreportedinTRPC7-/-mice;potentialroleinmyocardialapoptosisV1T>~43oC,V-dep,H+,activationpotentiatedbyPLCpathways,anandamide,2-AG,HETE,HPETE,capsaicin,olvanil,resiniferatoxin,ar-vanil,piperine,OEA,2-APB,DPBA,camphorcapsazepine,RuR,acylpolyamines,camphordesensitizesCalmodulin,TRPV3,TRPV2,PI3K,snapin,synaptotagminIX,β-tubulinInTRPV1-/-micedecreasedresponsetoheat,acidpH;diminishedstretch-evokedresponsesinbladder;upregulatedininflammatoryboweldisease,osteoarthritisV2T>~53oC?,Neuropeptideheadactivator,DPBA,2-APBRuR,La,SKF96365TRPV1,RGANophenotypeyetreportedinTRPV2-/-mice;roleinthermalpain,osmose...
