Role of the Gut Microbiome in the Pathogenesis of Obesity and Obesity-Related Metabolic Dysfunction.pdfVIP免费

AcceptedManuscriptRoleoftheGutMicrobiomeinthePathogenesisofObesityandObesity-RelatedMetabolicDysfunctionKristienE.Bouter,DaniëlH.vanRaalte,AlbertK.Groen,MaxNieuwdorpPII:S0016-5085(17)30141-5DOI:10.1053/j.gastro.2016.12.048Reference:YGAST60968Toappearin:GastroenterologyAcceptedDate:30December2016Pleasecitethisarticleas:BouterKE,vanRaalteDH,GroenAK,NieuwdorpM,RoleoftheGutMicrobiomeinthePathogenesisofObesityandObesity-RelatedMetabolicDysfunction,Gastroenterology(2017),doi:10.1053/j.gastro.2016.12.048.ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.MANUSCRIPTACCEPTEDACCEPTEDMANUSCRIPT1Title:roleofthegutmicrobiomeinthepathogenesisofobesityandobesity-relatedmetabolicdysfunctionKristienE.Bouter1,DaniëlH.vanRaalte2,3,AlbertK.Groen1,4andMaxNieuwdorp1,2,3,5*1DepartmentofVascularMedicine,AcademicMedicalCenter(AMC),UniversityofAmsterdam,TheNetherlands;2DiabetesCenter,DepartmentofInternalMedicine,VUUniversityMedicalCenter,Amsterdam,TheNetherlands;3InstituteforCardiovascularResearch(ICaR),VUUniversityMedicalCenter,Amsterdam,TheNetherlands;4DepartmentofPediatrics,LaboratoryofMetabolicDiseases,UniversityofGroningen,UMCG,Groningen,theNetherlands;5WallenbergLaboratory,UniversityofGothenberg,Gothenberg,Sweden.*Correspondingauthor:MaxNieuwdorp.DepartmentofExperimentalVascularMedicine,Meibergdreef9,RoomF4-159.2,1105AZAmsterdam,TheNetherlands.Tel.:+31205666612;E-mail:m.nieuwdorp@amc.uva.nlAbstract:146wordsManuscript:5813wordsincludingreferencesFigures:1MANUSCRIPTACCEPTEDACCEPTEDMANUSCRIPT2AbstractThepotentialroleofintestinalmicrobiotaintheetiologyofvarioushumandiseaseshasattractedmassiveattentioninthelastdecade.Assuch,theintestinalmicrobiotahasbeen...