Theranostics2019,Vol.9,Issue16http://www.thno.org4827TThheerraannoossttiiccss2019;9(16):4827-4840.doi:10.7150/thno.33812ResearchPaperSulforaphaneInhibitstheAcquisitionofTobaccoSmoke-InducedLungCancerStemCell-LikePropertiesviatheIL-6/ΔNp63α/NotchAxisChunfengXie1*,JianyunZhu2*,YeJiang3*,JiaqiChen1,XueqiWang1,ShanshanGeng1,JieshuWu1,CaiyunZhong1,4,XiaotingLi1,ZiliMeng51.DepartmentofNutritionandFoodSafety,SchoolofPublicHealth,NanjingMedicalUniversity,Nanjing,Jiangsu,211166,China.2.SuzhouDigestiveDiseasesandNutritionResearchCenter,NorthDistrictofSuzhouMunicipalHospital.TheAffiliatedSuzhouHospitalofNanjingMedicalUniversity,Suzhou,Jiangsu,215008,China.3.DepartmentofFoodandSchoolHygiene,TaizhouMunicipalCenterforDiseaseControlandPrevention,Taizhou,Zhejiang,318000,China.4.CenterforGlobalHealth,SchoolofPublicHealth,NanjingMedicalUniversity,Nanjing,Jiangsu,211166,China.5.DepartmentofRespiratoryMedicine,Huai'anFirstPeople'sHospital,NanjingMedicalUniversity,Huai'an,223300,Jiangsu,China.*ChunfengXie,JianyunZhuandYeJiangcontributedequallytothiswork.Correspondingauthors:CaiyunZhong,M.D.,Ph.D.,DABT,DepartmentofNutritionandFoodSafety,CenterforGlobalHealth,SchoolofPublicHealth,NanjingMedicalUniversity,101LongmianAve,Jiangning,Nanjing,211166,China.E-mail:cyzhong@njmu.edu.cn;Telephone:+862586868450;Fax:+862586868499.XiaotingLi,Ph.D.,DepartmentofNutritionandFoodSafety,SchoolofPublicHealth,NanjingMedicalUniversity,101LongmianAve,Jiangning,211166,China.E-mail:xiaotingli@njmu.edu.cn.ZiliMeng,DepartmentofRespiratoryMedicine,Huai'anFirstPeople'sHospital,NanjingMedicalUniversity,6BeijingRoadWest,Huai'an,223300,China.E-mail:mzl5001@126.com;Telephone:+8651780872618.©Theauthor(s).ThisisanopenaccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(https://creativecommons.org/licenses/by/4.0/).Seehttp://ivyspring.com/termsforfulltermsandconditions.Received:2019.02.03;Accepted:2019.06.11;Published:2019.07.09AbstractBackground:Tobaccosmoke(TS)criticallycontributestoth...
