TheapplicationofmesenchymalstemcellstotreatthermalandradiationburnsKathleenRodgersa,⁎,SachinS.JadhavbaCenterforInnovationinBrainSciences,CollegeofMedicine,DepartmentofPharmacology,UniversityofArizona,1501NorthCampbellAvenue,Tucson,AZ85724,UnitedStatesbBeckmanResearchCentre,DepartmentofExperimentalTherapeutics,CityofHope,Duarte,CA91010,UnitedStatesabstractarticleinfoArticlehistory:Received26May2017Receivedinrevisedform26September2017Accepted10October2017Availableonline12October2017Mesenchymalstemcells(MSCs)havebeendevelopedforanumberofindicationsduetotheirregenerativeandanti-inflammatoryphenotypesandtheirutilityisenhancedbythefactthatallogeneictransplantisfeasiblewiththiscelltype.Animalstudiesandearlyhumancasesindicatethatthishasthepotentialtobeanexcitingnewtherapyfortreatingchronicnon-healingwoundssuchasdiabeticulcers,burnsandcutaneousradiationburns.ThisreviewwillfocusontheuseofMSCstotreatthermalandradiationburns.Large,severeburnsaredifficulttotreatandposeamajorpublichealthburdenworldwide.Theyarecharacterizedbyanextensivelossoftheouterprotectivebarrier,delayedwoundhealing,increasedoxidativestressandaheightenedinflammatorystate.Thebreakdownoftheprotectivebarrierresultsinincreasedsusceptibilitytofluidlossandbacterialsepsis.Inthecaseofradiationburns,chronicinflammationcanresultinsubsequentwavesoftissueinjuryleadingtoskinbreakdownandnecrosis.TheaimofthisreviewistosummarizethecurrentknowledgeonMSCsintreatingthermalandradiationburnsalongwiththespecificscopeofcharacterizingthebiologicfunctionofMSCsthathelpenhancewoundhealinginthesechronicinjuries.©2017PublishedbyElsevierB.V.Keywords:ThermalburnsRadiationburnsMesenchymalstemcellsHealingDermalContents1.Introduction...............................................................752.Thermalandradiationburns:Pathophysiologyandcurrenttreatments.....................................763.Biologyofmesenchymalstemcells.....................................................763.1.Mesenchymalstemcellsandthermalburns.......................
