CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyJak/StatSignaling:IL-6ReceptorFamilyPTPPIASSHP-1SOCSTFTFp120ras-GAPSOCS3Stat3ErkmTORAktShcGRB2RasPI3KSHP-2ErkMEKRafStat3Stat3StatStatMcl-1JakJakStat3gp130EGFRSrcEGFErkErkIL-6SUMOCIS,SOCS,Mcl-1,APPs,TIMP-1,Pim-1,c-Myc,cytokines,TFs,etc.CrosstalkTumorCellsApoptosisRenewalofESCellsC/EBPβNF-κBAP-1etc.NucleusCytoplasmFeedbackInhibitionISRE/GASAccessoryTFMotifE-RasAktPI3KTumor-likePropertiesofESCells
