Seeonlineversionforlegendandreferences.1030Cell143,December10,2010©2010ElsevierInc.DOI10.1016/j.cell.2010.11.045SnapShot:InositolPhosphatesAceJ.HatchandJohnD.YorkHHMI,PharmacologyandCancerBiology,Biochemistry,DukeUniversity,Durham,NC27710,USAIPstructuralcofactorsADAR2TIR1AAAAAIP3213654OOOIP4OOOOIP4OOOOIP5OOOOOIP4OOOOIP3OOOIP4OOOOIP4OOOOIP3OOO1,5-IP8OOOOOOOO1-IP7OOOOOOO5-PP-IP4OOOOOOOO5-IP7OOOOOO1-IP7OOOOOIP4OOOOIP6OOOOOOIP6OOOOOOPho4Pho4PDbp5GleIDbp5GleIeRF1eRF3Pho85Pho80Pho85Pho80IP6OOOOOO213654OOO213654OOOPLCSTOPXYEASTPLC1--IPK2(ARG82)IPK1KCS1VIP1PLCβ,γ,δ,ε,ζ,ηIP3KA,B,CITPK1(IP56K)IPMK(IPK2)IPK1(IP5K)IP6K1,2,3VIP1,2(PPIP5K1,2)MAMMALIANGPCRRTKPIP2IPMKIP3KINPP5IPMKIPK1VIP1IP6KIP6KVIP1IP6KITPK1ITPK1IPMKPIP2CIC3Cl-channelENDOPLASMICRETICULUMIP3receptorPLASMAMEMBRANEKinaseactivityKinaseactivityblockedPho81Pho81NUCLEUSCYTOPLASMNUCLEUSCYTOPLASMPhosphatestarvationTranscriptionactivatedARG80ARG80MCM1MCM1AssemblyActivationKinaseindependentMCM1-ArgRcomplexKinasedependentNUCLEUSOtherrolesInositoldiphosphatescantransferphosphatenonenzymaticallytophosphoserinetogeneratediphosphatemodifedproteinsIP6K1(KCS1)generatedinositoldiphosphatesarerequiredforproperregulationoftelomerelengthIpk2regulatesactivityofSwi/SnfandIno80chromatin-remodelingcomplexesinyeastIP6K1(KCS1)isrequiredforpropervacuolemorphologyandresponsestoosmoticstressIP6stimulatesnonhomologousendjoiningthroughinteractionswithKuIP6(phytate)isimportantinplantbiologyandagricultureasamajorphosphatestoreNuclearporecomplexNuclearmRNAexportCYTOPLASMCYTOPLASMCYTOPLASMNUCLEUSmRNAmRNARibosomeTranslationterminationmRNAexportandtranslationIonchannelsPhosphatesensingTranscriptionAbundantphosphatePLC-dependentIPcodeIPK2ARG81Ca2+Cl-βCELLSecretoryvesiclesInsulin5-IP7OOOOOOO5-IP7OOOOOOOIP6OOOOOOAKTCYTOPLASMInsulinGSK3βAdipogenesisInsulinresistanceRRPvesiclesInsulinsecretionandAKTCa2+,finalreleaseEmbryonicdevelopmentIPMK(IPK2):Multipledefects,deathbyembryonicday10(mice)IPK1:Cilliaareshortenedandimmotilecausingpatterningdefects...
