KinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylaseRibosomalsubunitDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSeparationofSubunitsorCleavageProductsJoiningofSubunitsTranslocationTranscriptionalStimulatoryModificationTranscriptionalInhibitoryModificationCELLSIGNALINGTECHNOLOGYwww.cellsignal.comPathwayDiagramKeysSmad2/3PP2AROCKp38PI3KAktmTORMKK3/6CBPSmad4Smad1/5/8Smad1/5/8Smad4Smad2/3Smad2/3Smad2/3RasSOSErk1/2Smad1/5/8Smad1/5/8Smad4Smad4Smad2/3Smad2/3CBPSmad4Smad1/5/8Smad1/5/8JNKp38MKK3/6MKK4TGF-βLigands:TGF-βs,Activins,NodalsBMPLigands:BMP-2,-4,-7,MISPar6SARARhoATAK1/MLK3/MEKK1Smurf2Smurf1/2Smad6Smad7Smad7TMEPAIRac/Cdc42PKCmDiaPAKMLCLIMKCofilinc-AblSmurf1Smurf1TFTFLIMKCofilinp70S6KGRB2Shc4E-BP1/2TypeIReceptorTypeIIReceptorTypeIReceptorTypeIIReceptorActinPolymerizationStressFibersTranscriptionFactors:AP-1bZIPRUNXFoxbHLHhomeodomainSp1nuclearreceptorsIRF-7Corepressors:c-Ski/SnoNEvi1TGIFSIP1Tob(BMPonly)HDAC4/5Coactivators:CBP/p300SMIFMSG1ARC105CellAdhesionActinPolymerizationStressFibersNucleusCytoplasmTGF-bSignaling©2003–2014CellSignalingTechnology,Inc.
