ContentslistsavailableatScienceDirectSeminarsinCancerBiologyjournalhomepage:www.elsevier.com/locate/semcancerReviewReactiveoxygenspeciesincancerstemcellsofheadandnecksquamouscancerXuQiana,b,c,1,XiaoboNied,1,WenhaoYaoa,KonradKlinghammere,HolgerSudhofff,AndreasM.Kaufmanng,AndreasE.Albersa,⁎aDepartmentofOtorhinolaryngology,HeadandNeckSurgery,BerlinInstituteofHealth,Charité–UniversitätsmedizinBerlin,CorporatememberofFreieUniversitätBerlin,Humboldt-UniversitätzuBerlin,CampusBenjaminFranklin,Berlin,GermanybDivisionofMolecularDiagnostics,DepartmentofLaboratoryMedicine,ZhejiangCancerHospital,Hangzhou,PRChinacKeyLaboratoryofLaboratoryMedicine,MinistryofEducation,ZhejiangProvincialKeyLaboratoryofMedicalGenetics,WenzhouMedicalUniversity,Wenzhou,PRChinadKeyLaboratoryofReceptors-MediatedGeneRegulationandDrugDiscovery,SchoolofBasicMedicalSciences,HenanUniversity,Kaifeng,PRChinaeDepartmentofHematologyandOncology,BerlinInstituteofHealth,Charité–UniversitätsmedizinBerlin,CorporatememberofFreieUniversitätBerlin,Humboldt-UniversitätzuBerlin,CampusBenjaminFranklin,Berlin,GermanyfDepartmentofOtorhinolaryngology,HeadandNeckSurgery,KlinikumBielefeld,Bielefeld,GermanygClinicforGynecology,BerlinInstituteofHealth,Charité–UniversitätsmedizinBerlin,CorporatememberofFreieUniversitätBerlin,Humboldt-UniversitätzuBerlin,CampusBenjaminFranklin,Berlin,GermanyARTICLEINFOKeywords:CancerstemcellHeadandneckcancerReactiveoxygenspeciesDisulfiramNanotherapeuticsABSTRACTOneofthegreatestchallengesinsystemictreatmentofheadandnecksquamouscellcarcinoma(HNSCC)isasmalltumorcellpopulation,namely,cancerstem-likecells(CSC).CSCcanregenerateandmaintainahetero-genictumorbytheirself-renewalcapacity.Theirpotentialabilitytobemoreresistanttoandsurvivalafterchemo-andradiationtherapywasalsoidentified.Furtherstudieshaveshownthatreactiveoxygenspecies(ROS)contributetothisCSC-associatedresistance.Inthisreview,wefocusonthecurrentknowledgeofHNSCC-CSC,withregardtoROSasapossibleandnoveltherapeuticapproachintargeti...
