Seeonlineversionforlegendandreferences.1358Cell137,June26,2009©2009ElsevierInc.DOI10.1016/j.cell.2009.05.040SnapShot:FBoxProteinsIIJeffreyR.Skaar,1VincenzoD’Angiolella,1JuliaK.Pagan,1andMichelePagano1,21NYUSchoolofMedicineand2HowardHughesMedicalInstitute,NewYork,NY10016,USAmammalsfBoxProteinsubstratesBiologicalfunctionsofsubstrateskinase(s)Fbxw1/β-TRCP1(Fbxw11/β-TrCP2)Atf4txnfactor,stresspathwaysβ-Catenintxnactivator,WntsignalingGsk3BimELBH3homology,inducesapoptosisRsk1,Rsk2BoraAurorakinaseactivator,spindlestabilityGsk3,Plk3Cdc25Aphosphatase,CDKactivator,cellcycleChk1Cdc25Bphosphatase,CDKactivator,cellcycleClaspinreplication/DNAdamageresponsePlk1CyclinD1cyclin,cellcycleDlgcellcontactandpolarityEmi1Fboxprotein,APC/Cinhibitor,cellcyclePlk1FancMhelicase,DNAdamageresponsePlk1Fgd1GEF,Cdc42regulationFgd3GEF,Cdc42regulationGhrreceptor,growthhormonesignalingH-RasGTPase,signaling,cellgrowthHsf1txnfactor,heatshockresponsePlk1Ifnrreceptor,cytokinesignalingIκBαinhibitorofNF-κBIkkβMcl1BH3homology,inhibitsapoptosisGsk3p100txnfactor,NF-κBsignalingIkkαp105txnfactor,NF-κBsignalingIkkβp53txnfactor,tumorsuppressorIkk2p63txnfactor,epithelialdifferentiationPc2transmembraneprotein,calciumsignalingPdcd4EIF4Ainhibitor,proteinsynthesisS6k1Per1txnactivator,circadianrhythmsCk1εPer2txnactivator,circadianrhythmsCk1εPrl-Rreceptor,growthhormonesignalingPro-caspase3caspase,apoptosisPtt-g1/Securinseparaseinhibitor,spindlecheckpointRcan1calcineurin-dependentsignalingResttxnrepressor,cellcycle,differentiationSipa1l1/SparGAP,signaltransductionPlk2Smad3txnfactor,BMP/TGFsignalingSnailtxnrepression,EMTGsk3Stat-1txnfactor,IFNsignalingWee1kinase,CDKinhibitor,cellcyclePlk1,Cdk1Fbxw2Gcmatxnfactor,placentadevelopmentFbxw5Tsc2GAP,mTORpathwaysFbxw7/Cdc4Aurora-Akinase,cellcyclec-Juntxnfactor,cellgrowth/proliferationGsk3c-Mybtxnfactor,cellgrowth/proliferationNlkc-Myctxnfactor,cellgrowth/proliferationGsk3CyclinE1/E2cyclins,cellcycleCdk2,Gsk3mTorkinase,mTORgrowthpathwaysNotch1transmembranereceptor...
