ArticleFTOPlaysanOncogenicRoleinAcuteMyeloidLeukemiaasaN6-MethyladenosineRNADemethylaseHighlightsdFTOishighlyexpressedincertainsubtypesofAMLssuchasMLL-rearrangedAMLdFTOpromotesleukemiconcogene-mediatedcelltransformationandleukemogenesisdFTOtargetsasetofgenes(e.g.,ASB2andRARA)inAMLasanm6ARNAdemethylasedTheFTOxASB2/RARAaxismediatesAMLcellgrowthand(ATRA-induced)differentiationAuthorsZejuanLi,HengyouWeng,RuiSu,...,JieJin,ChuanHe,JianjunChenCorrespondencechuanhe@uchicago.edu(C.H.),chen3jj@ucmail.uc.edu(J.C.)InBriefLietal.showthatFTO,anN6-methyladenosine(m6A)demethylase,ishighlyexpressedinsubtypesofAML,promotesleukemogenesis,andinhibitsall-trans-retinoicacid-inducedleukemiacelldifferentiation.FTOexertsitsoncogenicrolebyregulatingmRNAtargetssuchasASB2andRARAbyreducingtheirm6Alevels.AccessionNumbersGSE34184GSE30285GSE76414GSE84944GSE85008Lietal.,2017,CancerCell31,1–15January9,2017ª2016ElsevierInc.http://dx.doi.org/10.1016/j.ccell.2016.11.017CancerCellArticleFTOPlaysanOncogenicRoleinAcuteMyeloidLeukemiaasaN6-MethyladenosineRNADemethylaseZejuanLi,1,7,10HengyouWeng,1,2,10RuiSu,2,10XiaochengWeng,3,8,10ZhixiangZuo,1,2,9,10ChenyingLi,2,4HuilinHuang,2SigridNachtergaele,3LeiDong,2ChaoHu,1,2,4XiQin,2LichunTang,5YunguiWang,1,2,4Gia-MingHong,1HaoHuang,1XiaoWang,3PingChen,1SandeepGurbuxani,6StephenArnovitz,1YuanyuanLi,1ShenglaiLi,1JenniferStrong,2MaryBethNeilly,1RichardA.Larson,1XiJiang,1,2PuminZhang,5JieJin,4ChuanHe,3,*andJianjunChen1,2,11,*1SectionofHematology/Oncology,DepartmentofMedicine,UniversityofChicago,Chicago,IL60637,USA2DepartmentofCancerBiology,UniversityofCincinnatiCollegeofMedicine,Cincinnati,OH45219,USA3DepartmentsofChemistry,BiochemistryandMolecularBiology,InstituteforBiophysicalDynamics,HowardHughesMedicalInstitute,UniversityofChicago,Chicago,IL60637,USA4KeyLaboratoryofHematopoieticMalignancies,DepartmentofHematology,TheFirstAffiliatedHospitalofZhejiangUniversity,Hangzhou,Zhejiang310003,China5DepartmentofMolecularPhysiologyandBiophysics,BaylorCollegeofMedicine,Hou...
