HumanGeneSymbol(Localization)PotentiallyRegulatedbyPotentiallyRegulatesCellularandDevelopmentalRolesMutantMousePhenotypeRoleinCancer/HumanDiseaseFOXA1(14q21.1)FOXA2,FOXA3,RXRA,PMA,MSA,Ie86,INS1,NR0B2,DHT,POU5F1,FOXD3,GR,PRKACA,LRP5,ERGCG,TCF1,TFF1,INS1,PRDM15,XBP1,PISD,COL18A1,NRIP1,ATP5J,DSCAM,NDUFV3,SOD1,LIN52,PFKFB1Epithelialcelldifferentiation;branchingmorphogenesis;developmentoflung,liver,prostate,andpancreas.Severegrowthretardation,hypogly-cemia,electrolyteimbalance.Diesoonafterbirth.ExpressedinluminaltypeAbreastcancer;expressedinhumanprostatecarcinomas.FOXA2(20p11.21)SHH,GLI1,FOXA2,LPS,PMA,NR1H4,IL13,RNF111,IFT88,NR4A3,DYNC2LI1,GATA6,SFTPC,INS1,1-alpha,vitaminD3FOXA1,FOXA2,Pepck,ABCB4,ALDOB,TCF1,SHH,HNF4A,SLC10A1,INS1,WNT7B,PDX1,DLK1,PCK1,FOXA3Epithelialcelldifferentiation;branchingmorphogenesis;developmentofforebrain,lung,liver,prostate,andpancreas.Nodeandnotochordmissing.Foregutmorphogenesisdefective.EmbryosdiebyE10.Conditionalbcellknockoutcauseshypoglycemia.Expressedinneuro-endocrinesmallcellcarcinomas.FOXA3(19q13.32)TCF1,FOXA2,TCF2,PMA,Ie86,AGN194204,fenofibrate,pirinixicacid,CLOCK,NR0B2,GR,PRKACAPepck,FOXA1,FOXA2,TF,TAT,CYP2C8,CYP2C9,CYP2C19,CYP3A4,SLC2A2,TCF1,NR3C1Cellglucosehomeostasisandresponsetostarvation.Expressionofseveralliver-specificgenesisreduced.FOXB1(15q22.2)CTNNB1Developmentofneuraltube,mammillarybodynerveprocess.Variablephenotypewithneuraltubedefects,growthretardation,andre-ducedlactationinsurvivingfemales.FOXC1(6p25.3)ER,valproicacid,trichostatinA,LY294002,camptothecin,tert-butyl-hydroquinone,TGFB1,Erk,EGF,FLNALFNG,EFNB2,DLL1,MESP1,NOTCH1,HES5,MESP2,TCF15,luciferasereportergene,TBX1,glycosamino-glycanGermcellmigration;mesenchy-malcelldifferentiation;develop-mentofkidney,skeleton,brain,ureter,heart,lacrimalgland,ovarianfollicle,andtooth.Hydrocephalus,ocular,skeletal,renal,andcardiovascularabnor-malities.Dieshortlyafterbirth.Abnormalitiesinanteriorsegmentinheterozygotes.Functionsastumorsuppressor.AssociatedwithAxenfeld-Riegersyndromean...
