REVIEWOpenAccessFerroptosis,anewformofcelldeath:opportunitiesandchallengesincancerYanhuaMou1,2†,JunWang2†,JinchunWu1,DanHe3,ChunfangZhang4,ChaojunDuan1,2,5*andBinLi1,2*AbstractFerroptosisisanoveltypeofcelldeathwithdistinctpropertiesandrecognizingfunctionsinvolvedinphysicalconditionsorvariousdiseasesincludingcancers.Thefast-growingstudiesofferroptosisincancerhaveboostedaperspectiveforitsusageincancertherapeutics.Here,wereviewthecurrentfindingsofferroptosisregulationandespeciallyfocusonthefunctionofncRNAsinmediatingtheprocessofcellferroptoticdeathandonhowferroptosiswasinrelationtootherregulatedcelldeaths.Aberrantferroptosisindiversecancertypesandtissuesweresummarized,andweelaboratedrecentdataaboutthenovelactorsofsome“conventional”drugsornaturalcompoundsasferroptosisinducersincancer.Finally,wedeliberatefutureorientationforferroptosisincancercellsandcurrentunsettledissues,whichmayforwardthespeedofclinicaluseofferroptosisinductionincancertreatment.Keywords:Ferroptosis,Apoptosis,Autophagy,NcRNAs,Cancers,P53BackgroundFerroptosiswasfirstproposedbyDixonasanovelcelldeathin2012[1].Unlikeautophagyandapoptosis,fer-roptosisisaniron-dependentandreactiveoxygenspecies(ROS)-reliantcelldeathwithcharacteristicsmainlyofcytologicalchanges,includingdecreasedorvanishedmitochondriacristae,arupturedoutermitochondrialmembrane,andacondensedmitochondrialmembrane[2–6].Thesecellabnormalitiesresultedfromthelossofselectivepermeabilityofplasmamembraneduetoin-tensemembranelipidperoxidationandtheoccurrenceofoxidativestress(Table1)[7].Researchesindicatedthatferroptosiscouldbetriggeredbydiversephysiologicalconditionsandpathologicalstressesinhumansandanimals[8].Ferroptosisisgrad-uallyacceptedasanadaptivefeaturetoeliminatethema-lignantcells.Itplaysapivotalroleinthedepressionoftumorigenesisbyremovingthecellsthataredeficientinkeynutrientsintheenvironmentordamagedbyinfectionorambientstress[9].Studieshaveshownthattheclassicoxidativestresspathwaywasanimportantcausativefactortoinduceferroptosis.Although...
