1Drug-inducedsenescentmultiplemyelomacellselicitNKcellproliferationbydirectorexosome-mediatedIL15trans-presentationCristianaBorrelli1†,BiancamariaRicci^,ElisabettaVulpis1,CinziaFionda1,MariaRosariaRicciardi2,MariaTeresaPetrucci3,LauraMasuelli4,AgnesePeri1,MarcoCippitelli1,AlessandraZingoni1,AngelaSantoni1#*,andAlessandraSoriani1*1DepartmentofMolecularMedicine,SapienzaUniversityofRome,LaboratoryaffiliatedtoIstitutoPasteurItalia–FondazioneCenciBolognetti,Rome,Italy;2Hematology,DepartmentofClinicalandMolecularMedicine,SapienzaUniversityofRome,Italy;3DivisionofHematology,DepartmentofCellularBiotechnologiesandHematology,SapienzaUniversityofRome,Italy;4DepartmentofExperimentalMedicine,SapienzaUniversityofRome,Rome,Italy;†CenterforLifeNanoScience@Sapienza,IstitutoItalianodiTecnologia,Rome,Italy;^DepartmentofOrthopaedics,WashingtonUniversityinSt.Louis-SchoolofMedicine;#NeuromedI.R.C.C.S.-IstitutoNeurologicoMediterraneo,Pozzilli(IS),Italy*theseauthorscontributedequallytothisworkRunningtitle:SenescentMMpromotesIL15-mediatedNKcellproliferationKeywords(5):NKcells,MultipleMyeloma,IL15trans-presentation,proliferation,exosome*Correspondenceto:A.SorianiorA.Santoni,DepartmentofMolecularMedicine,SapienzaUniversityofRome,VialeReginaElena291,00161,Rome,Italy.Telephone:+39-0649255152;FAX:+39-0644340632.Email:alessandra.soriani@uniroma1.itorangela.santoni@uniroma1.itDisclosureofpotentialconflictsofinterestTheauthorsdeclarenopotentialconflictsofinterest.FundingThisworkwassupportedbyItalianAssociationforCancerResearch(AIRC5x1000cod.9962),theSapienzaUniversityofRome(Progettodiricerca2016,cod.:RM116154C8F24748).E.V.issupportedbyafellowshipfromAIRC.Abstractwordcount:225Bodywordcount:3311Numberoffigures:6Numberoftables:1Numberofsupplementaryfigures:5Numberofsupplementarytables:2onJune6,2018.©2018AmericanAssociationforCancerResearch.cancerimmunolres.aacrjournals.orgDownloadedfromAuthormanuscriptshavebeenpeerreviewedandacceptedforpublicationbuthavenotyetbeenedited.AuthorManuscriptPublishe...
