FullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=kaup20Downloadby:[UniversityofWaterloo]Date:14November2017,At:00:47AutophagyISSN:1554-8627(Print)1554-8635(Online)Journalhomepage:http://www.tandfonline.com/loi/kaup20Autophagyandinnateimmunity:InsightsfrominvertebratemodelorganismsCheng-JuKuo,MaleneHansen&EmilyTroemelTocitethisarticle:Cheng-JuKuo,MaleneHansen&EmilyTroemel(2017):Autophagyandinnateimmunity:Insightsfrominvertebratemodelorganisms,Autophagy,DOI:10.1080/15548627.2017.1389824Tolinktothisarticle:http://dx.doi.org/10.1080/15548627.2017.1389824Acceptedauthorversionpostedonline:13Nov2017.SubmityourarticletothisjournalViewrelatedarticlesViewCrossmarkdataACCEPTEDMANUSCRIPTACCEPTEDMANUSCRIPTAutophagyandinnateimmunity:InsightsfrominvertebratemodelorganismsCheng-JuKuo1,2,MaleneHansen3andEmilyTroemel11DivisionofBiologicalSciences,UniversityofCalifornia,SanDiego,LaJolla,CA92093,USA.2InstituteofBasicMedicalSciences,CollegeofMedicine,NationalChengKungUniversity,Tainan,Taiwan.3SanfordBurnhamPrebysMedicalDiscoveryInstitute,ProgramofDevelopment,AgingandRegeneration,10901NorthTorreyPinesRoad,LaJolla,CA92037,USA.Correspondence:ET(etroemel@ucsd.edu)andMH(mhansen@sbpdiscovery.org)ABSTRACTMacroautophagy/autophagyisafundamentalintracellulardegradationprocesswithmultiplerolesinimmunity,includingdirecteliminationofintracellularmicroorganismsvia‘xenophagy.’Inthisreview,wesummarizestudiesfromthefruitflyDrosophilamelanogasterandthenematodeCaenorhabditiselegansthathighlighttherolesofautophagyininnateimmuneresponsestoviral,bacterial,andfungalpathogens.Researchfromthesegeneticallytractableinvertebrateshasuncoveredseveralconservedimmunologicalparadigms,suchasdirecttargetingofintracellularpathogensbyxenophagyandregulationofautophagybypatternrecognitionreceptorsinD.melanogaster.AlthoughC.eleganshasnoknownpatternrecognitionreceptors,thisDownloadedby[UniversityofWaterloo]at00:4714November2017ACCEPTEDMANUSCRIPTACCEPTEDMANUSCRI...
