TransportComplexCategoryS.cerevisiaeKaryopherins&OtherReceptorsCargo(s)EssentialMetazoanKaryopherins&OtherReceptorsCargo(s)ImportIKap95Kap60adaptorforcNLSproteinsYesImportin-b1Importin-aadaptorforcNLSproteins,SnurportinadaptorforUsnRNPsIIKap95—YesImportin-b1SREBP-2,HIVRevandTAT,CyclinBKap104Nab2,Hrp1(mRNA-bindingproteins)t.s.TransportinorTransportin2PY-NLS-containingproteins,mRNA-bindingproteins,histones,ribosomalproteinsKap123SRPproteins,histones,ribo-somalproteinsNoImportin4histones,ribosomalproteinS3a,TransitionProtein2Kap111/Mtr10Npl3(mRNA-bindingprotein),tRNAst.s.TransportinSR1orSR2SRproteins,HuRKap121/Pse1ribosomalproteins,Yra1,Spo12,Ste12,Yap1,Pho4,histonesYesImportin5/Importin-b3/RanBP5histones,ribosomalproteinsKap119/Nmd5ribosomalpro-teins,histones,Hog1,Crz1,Dst1NoImportin7GR,ribosomalpro-teins,Smad,ERKKap108/Sxm1Lhp1,ribosomalproteinsNoImportin8SRP19,SmadKap114TBP,histones,Nap1,Sua7NoImportin9histones,ribosomalproteinsKap122/Pdr6Toa1andToa2,TFIIANo——Kap120Rpf1No—————Importin11UbcM2,rpL12Ntf2Ran/Gsp1(GDP-boundform)YesNTF2Ran(GDP-boundform)Import/ExportIIIKap142/Msn5Replicationpro-teinA(import),Pho4,Crz1,Cdh1(export)No—————Importin13UBC9,Y14(import),eIFIA(export)ExportIVCrm1/Xpo1Leucine-richNESsequencesYesCRM1/Exportin1Leucine-richNESsequencesKap109/Cse1Kap60/Srp1YesCASImportin-afamilymembersKap127/Los1tRNAsNoExportin-ttRNAs———Exportin4eIF5A———Exportin5pre-miRNA———Exportin6Profilin,actin———RanBP16/Exportin7p50-RhoGAPVCrm1/Xpo1Nmd3adaptorfor60SribosomalsubunitYesCRM1/Exportin1NMD3adaptorfor60SribosomalsubunitMex67-Mtr260Svia5SrRNAYes——Arx160SribosomalsubunitNo——Crm1/Xpo1Ltv1putativeadaptorfor40SribosomalsubunitYesCRM1/Exportin140SribosomalsubunitVIMex67-Mtr2Npl3,Yra1,andHpr1adaptorsformRNAYesTAP/NXF1-p15/NXT1REF/AlyadaptorformRNASnapShot:NuclearTransportElizabethJ.Tran,TimothyA.Bolger,andSusanR.WenteCellandDevelopmentalBiology,VanderbiltUniversityMedicalCenter,Nashville,TN37232,USA420Cell131,October19,2007©2007ElsevierInc.DOI1...