REVIEW1704007(1of15)©2018WILEY-VCHVerlagGmbH&Co.KGaA,Weinheimwww.advmat.deEmergingStrategiesofCancerTherapyBasedonFerroptosisZheyuShen,JibinSong,BryantC.Yung,ZijianZhou,*AiguoWu,*andXiaoyuanChen*DOI:10.1002/adma.2017040071.IntroductionFerroptosisisaformofregulatedcelldeaththatisiron-andreactiveoxygenspecies(ROS)-dependent.Interestingly,thediscoveryofferroptosislongprecededitsconceptionin2012byStockwellandco-workers.[1]In2001,auniqueformofpro-grammednerve-celldeathcausedbyoxidativestresswasfoundandtermedoxytosis.[2]Thepreliminaryresearchinvolvingthisformofcelldeathprovidedfoundationalevidencehighlyrelevanttoferroptosis.[3]Studiesconductedwithconditionalknockoutmiceforglutathioneperoxidase4(GPX4)providedFerroptosis,anewformofregulatedcelldeaththatisiron-andreactiveoxygenspeciesdependent,hasattractedmuchattentionintheresearchcom-munitiesofbiochemistry,oncology,andespeciallymaterialsciences.Sincethefirstdemonstrationin2012,aseriesofstrategieshavebeendevelopedtoinduceferroptosisofcancercells,includingtheuseofnanomaterials,clinicaldrugs,experimentalcompounds,andgenes.Aplethoraofresearchworkhasoutlinedtheblueprintofferroptosisasanewoptionforcancertherapy.How-ever,thepublishedferroptosis-relatedreviewshavemainlyfocusedonthemechanismsandpathwaysofferroptosis,whichmotivatedthiscontributiontobridgethegapbetweenbiologicalsignificanceandmaterialdesign.There-fore,itistimelytosummarizethepreviouseffortsontheemergingstrategiesforinducingferroptosisandshedlightonfuturedirectionsforusingsuchatooltofightagainstcancer.Here,thecurrentstrategiesofcancertherapybasedonferroptosiswillbeelaborated,thedesignconsiderationsandtheadvantagesandlimitationsarehighlighted,andfinallyafutureperspectiveonthisemergingfieldisgiven.CancerTherapyDr.Z.Shen,Prof.A.WuCASKeyLaboratoryofMagneticMaterialsandDevicesKeyLaboratoryofAdditiveManufacturingMaterialsofZhejiangProvinceDivisionofFunctionalMaterialsandNanodevicesNingboInstituteofMaterialsTechnologyandEngineeringChineseAcademyofSciences1219ZhongGuanWest...
