CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyPI3Kinase/AktSignalingAktATM/ATRDNA-PKAktp70S6KPI3KPI3KPaxillinGSK-3PHLPP1/2CTMPLaminAp47phoxPP2ATpl2IKKαeNOSGSATP-CitrateLyaseBadBcl-2FoxO1TSC2PDCD4AS160PFKFB2HexokinaseIIPIP5KS6Skp2SCFp53MDM2BimBaxp27Kip1p21Waf1/Cip114-3-3PalladinGirdinCyclinD1GαGTPPTENPDK1SykJak1FAKILKPI3KPI3KPI3KXIAPWee1CDK2Myt1Gab1Gab2IRS-1PTENIntegrinCytokineReceptorPDK1GβγBCAPLynAgAtaxin-1HuntingtinGABAARPRAS40GPCRRTKCD19BCRPIP3PIP3RaptorGβLmTORDEPTORmTORC1mTORC2mTORRictorSin1PRR5DEPTORGβLmTORC1mTORC24E-BP1ATG13CyclinATSC1TRAF6NEDD1-4TBK1α/βα/βBlocksAggregationPromotesNeuroprotectionSynapticSignalingmIgmIgCytosolicSequestrationCardiovascularHomeostasisNF-κBPathwayOrganizationofNuclearProteinsNeutrophilRespiratoryBurstCellCycleApoptosisMigrationAggregationNeurodegenerationInhibitsApoptosisInhibitsAutophagyGlycogenSynthesisFattyAcidSynthesisGlucoseTransportGlycolysisMembraneRecruitmentandActivationMembraneRecruitmentandActivationDNADamageProteinSynthesisSurvivalProliferationMigrationGlucoseMetabolismNeuroscienceOther