FullTerms&Conditionsofaccessandusecanbefoundathttps://www.tandfonline.com/action/journalInformation?journalCode=kaup20AutophagyISSN:1554-8627(Print)1554-8635(Online)Journalhomepage:https://www.tandfonline.com/loi/kaup20CircularRNAcircHIPK3modulatesautophagyviaMIR124-3p-STAT3-PRKAA/AMPKαsignalinginSTK11mutantlungcancerXiuyuanChen,RuiMao,WenmeiSu,XiaYang,QianqianGeng,ChunfangGuo,ZhuwenWang,JunWang,LauraA.Kresty,DavidG.Beer,AndrewC.Chang&GuoanChenTocitethisarticle:XiuyuanChen,RuiMao,WenmeiSu,XiaYang,QianqianGeng,ChunfangGuo,ZhuwenWang,JunWang,LauraA.Kresty,DavidG.Beer,AndrewC.Chang&GuoanChen(2019):CircularRNAcircHIPK3modulatesautophagyviaMIR124-3p-STAT3-PRKAA/AMPKαsignalinginSTK11mutantlungcancer,Autophagy,DOI:10.1080/15548627.2019.1634945Tolinktothisarticle:https://doi.org/10.1080/15548627.2019.1634945ViewsupplementarymaterialAcceptedauthorversionpostedonline:23Jun2019.Publishedonline:28Jun2019.SubmityourarticletothisjournalArticleviews:308ViewCrossmarkdataRESEARCHPAPERCircularRNAcircHIPK3modulatesautophagyviaMIR124-3p-STAT3-PRKAA/AMPKαsignalinginSTK11mutantlungcancerXiuyuanChena,b,RuiMaoc,WenmeiSud,XiaYange,QianqianGenge,ChunfangGuob,ZhuwenWangb,JunWanga,LauraA.Krestyb,DavidG.Beerb,AndrewC.Changb,andGuoanChenfaDepartmentofThoracicSurgery,PekingUniversityPeople’sHospital,Beijing,China;bSectionofThoracicSurgery,DepartmentofSurgery,RogelCancerCenter,UniversityofMichigan,AnnArbor,USA;cCancerCenter,XinjiangMedicalUniversity,Urumqi,China;dDepartmentofOncology,AffiliatedHospitalofGuangdongMedicalUniversity,Zhanjiang,China;eTheFirstAffiliatedHospital,XianJiaotongUniversity,Xi’an,China;fSchoolofMedicine,SouthernUniversityofScienceandTechnology,Shenzhen,ChinaABSTRACTTheroleofcircularRNAincancerisemerging.AnewlyreportedcircularRNAHIPK3(circHIPK3)iscriticalincellproliferationofvariouscancertypes,althoughitsroleinnon-smallcelllungcancer(NSCLC),hasyettobeelucidated.OurresultsprovidedevidencethatsilencingofcircHIPK3significantlyimpairedcellproliferation,migration,invasionan...
