Mini-reviewOxidativestressanddietaryphytochemicals:RoleincancerchemopreventionandtreatmentShireenChikaraa,LokeshDalasanurNagaprashanthaa,JyotsanaSinghalb,DavidHorneb,SanjayAwasthic,SharadS.Singhala,*aDepartmentofMedicalOncology,BeckmanResearchInstituteofCityofHope,ComprehensiveCancerCenterandNationalMedicalCenter,Duarte,CA91010,USAbDepartmentofMolecularMedicine,BeckmanResearchInstituteofCityofHope,ComprehensiveCancerCenterandNationalMedicalCenter,Duarte,CA91010,USAcDepartmentofMedicalOncology,TexasTechUniversityHealthSciencesCenter,Lubbock,TX79430,USAarticleinfoArticlehistory:Received29September2017Receivedinrevisedform23October2017Accepted2November2017Keywords:CarcinogenesisChemopreventionChemotherapyOxidativestressNrf2PhytochemicalsabstractSeveralepidemiologicalobservationshaveshownaninverserelationbetweenconsumptionofplant-basedfoods,richinphytochemicals,andincidenceofcancer.Phytochemicals,secondaryplantmetab-olites,viatheirantioxidantpropertyplayakeyroleincancerchemopreventionbysuppressingoxidativestress-inducedDNAdamage.Inaddition,theymodulateseveraloxidativestress-mediatedsignalingpathwaysthroughtheiranti-oxidanteffects,andultimatelyprotectcellsfromundergoingmolecularchangesthattriggercarcinogenesis.Inseveralinstances,however,thepro-oxidantpropertyofthesephytochemicalshasbeenobservedwithrespecttocancertreatment.Further,invitroandinvivostudiesshowthatseveralphytochemicalspotentiatetheefficacyofchemotherapeuticagentsbyexacerbatingoxidativestressincancercells.Therefore,wereviewedmultiplestudiesinvestigatingtheroleofdietaryphytochemicalssuchas,curcumin(turmeric),epigallocatechingallate(EGCG;greentea),resveratrol(grapes),phenethylisothiocyanate(PEITC),sulforaphane(cruciferousvegetables),hesperidin,quercetinand20-hydroxyflavanone(2HF;citrusfruits)inregulatingoxidativestressandassociatedsignalingpathwaysinthecontextofcancerchemopreventionandtreatment.©2017ElsevierB.V.Allrightsreserved.1.IntroductionConsumptionofplant-basedfoods,suchasfruits,vegetables,andwholegra...
